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Hereditary hypophosphatemia (XLH) is a rare, inherited disease. Loss-of-function mutation in PHEX results in excess fibroblast growth factor 23 (FGF23) production and manifests as rickets in children and osteomalacia in adults. FGF23 is a hormone that reduces renal phosphate reabsorption, decreases
EXPERIMENTAL PLAN Study Design The proposed study is a Phase 3, double-blinded, randomized controlled study. All of the 80 patients, both placebo and denosumab groups, will adhere to the same protocol. Patient screening will be performed by the orthopaedic surgeons (Donald Longjohn, MD and Daniel
Stage 1:
Bone marrow will be collected from otherwise healthy patients undergoing orthopedic surgery - arthroplasty for the treatment of degenerative joint disease or traumatised patients. The bone marrow will be collected from disposable tissue that is removed during the normal sequence of the
Clinical data (range of motion of lower limb joints, sociodemographic score dataset, WOMAC score, EQ-5D score, Harris Hip Score, radiological evaluation (OA group only), routine laboratory parameters, and bone metabolism parameters)
Osteogenic, chondrogenic, and adipogenic differentiation is proofed