Carb-Loading: Freeze-Induced Activation of the Glucose-Responsive ChREBP Transcriptional Network in Wood Frogs.
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Abstrak
The freeze-tolerant wood frog, Rana sylvatica, is one of few vertebrate organisms that can tolerate freezing, with up to 70% of its total body water being converted into extracellular ice. Physiologically, wood frogs show no signs of muscle movement, breathing, heartbeat, or brain activity for several weeks or months at a time but emerge unharmed upon thawing. Given that wood frogs rely mainly on carbohydrate metabolism during freezing, the involvement of the carbohydrate-responsive element-binding protein (ChREBP) in response to freezing is of interest. In liver tissue, protein and transcript levels of ChREBP increased by