Dietary pyridoxine and the susceptibility to limbic motor seizures in rats.

Dietary pyridoxine (PN) deficiency in adult female rats produced a 32% decrease in hippocampal gamma-aminobutyric acid content, measured by a radioreceptor assay. No spontaneous seizures were observed in pyridoxine-deficient animals, but the seizure latency after a systemic kainic acid challenge decreased by 35%. The results suggest that latency is a useful measure of limbic seizure susceptibility; this susceptibility can be manipulated by diet; and in adults pyridoxine-dependent mechanisms normally participate in preventing, rather than initiating, limbic seizures.