Hyperchloremic metabolic acidosis following plasma exchange during myasthenia gravis crisis.

BACKGROUND

Therapeutic plasma exchanges are increasingly used, notably during myasthenia gravis crisis. Repeated exchanges may induce severe adverse events.

METHODS

We reported a case of symptomatic hyperchloremic metabolic acidosis following a therapeutic plasma exchange. Analysis of 4% albumin substitution solution revealed a chloride concentration of 145 mmol/L, which could explain this acidosis.

CONCLUSIONS

Infusion of high volume of 4% albumin during plasma exchanges may produce hyerchloremic metabolic acidosis.

CONCLUSIONS

Special attention should be paid when repeated plasma exchanges are performed. J. Clin. Apheresis 31:479-480, 2016. © 2015 Wiley Periodicals, Inc.