Biomarkers 2015
Uric acid correlates to oxidation and inflammation in opposite directions in women.
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OBJECTIVE
To evaluate the association of uric acid (UA) levels with a panel of markers of oxidative stress and inflammation.
METHODS
Plasma UA levels, along with a panel of oxidative stress and inflammatory markers, were measured in 755 Chinese women.
RESULTS
Plasma UA levels were inversely associated with urinary levels of the oxidative stress marker F2-isoprostanes and positively correlated to levels of inflammatory markers, such as C-reactive protein and some proinflammatory cytokines (tumor necrosis factor-α and interleukin-6) in blood as well as prostaglandin E2 metabolites in urine.
CONCLUSIONS
Plasma UA levels correlate to oxidation and inflammation biomarkers in opposite directions in women.
