Journal of the Science of Food and Agriculture 2020-Feb
Topical Capsaicin Cream With Moderate Exercise Protects Against Hepatic Steatosis, Dyslipidemia And Increased Blood Pressure In Hypoestrogenic Obese Rats.
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BACKGROUND
The aim of this study was to evaluate the effects of capsaicin (Cap), moderate exercise (Ex) and their combination on arterial blood pressure (BP) and metabolic complications in hypoestrogenic (HE) obese (HEOb) rats. Female Wistar rats were ovariectomized and given 300 g L-1 sucrose solution (HEOb), or purified water (HE) ad libitum, during 28 weeks. After shaving the abdominal skin, cold cream vehicle was applied to Sedentary (Sed) and Exercise (Ex) groups, and Cap cream 0.75 g kg-1 was applied to Ex groups. Ex groups ran on a treadmill every day for 20 min at speeds from 0.15 to 0.3 m s-1 . For combination groups (Cap+Ex), topical Cap was applied 90 min before Ex. The treatments were performed for 6 weeks, and BP was recorded before and at the end of the experimental protocol. The animals were killed by decapitation and blood and tissues were obtained to perform oxidative profile, as well as to biochemical and histologic studies.