Oral Squamous Cell Carcinoma (OSCC)

Saliva collection

Instituto do Câncer do Estado de São Paulo

Determination of ALDH1b1 and ALDH2 Polymorphisms Frequency in the Brazilian Population

Determine the frequency of ALDH1b1 and ALDH2 polymorphisms in OSCC patients and healthy volunteers.

Instituto do Cancer do Estado de São Paulo

Instituto de Ciências Biomédicas da Universidade de São Paulo

Oral intake of slow-release L-cysteine 200 mg before challenge with ethanol.

Oral intake of identically-looking placebo capsules

Gastritis, Atrophic

Bind and inactivate acetaldehyde formed from ethanol by covalent binding to L-cysteine

Slow-release L-cysteine

Uppsala University

L-cysteine Prevents Stomach Exposure to Carcinogenic Acetaldehyde

Slow-release L-cysteine Capsule Prevents Carcinogenic Gastric Acetaldehyde Exposure in Helicobacter-associated Atrophic Gastritis

Production of inert 4-methyltiazolidine-2-carboxylic acid after binding to L-cysteine

Per Hellström

Professor

Biohit Oyj, Helsinki, Finland

University of Helsinki

Åbo Akademi University

Clinical Trial Consultants, Uppsala, Sweden

Disulfiram/copper combination will be started on the 5th postoperative day and before the initiation of the standard radiochemotherapy (fractionated irradiation with a total dose of 60 Gy with concomitant 75 mg/m2 body surface temozolomide each day, including weekends, during irradiation). After completion of the radiation therapy patients will receive maintenance temozolomide 150-200 mg/m2 body surface on Days 1-5 every 28 days for 6 months. Daily administration of disulfiram and copper will take place for the whole study period.
NOTE: Patients may receive additional maintenance temozolomide at the discretion of the treating medical oncologist.

Glioblastoma Multiforme

Temozolomide

Disulfiram

Copper

Olympion Medical Center

Disulfiram/Copper Combination In The Treatment of Newly Diagnosed Glioblastoma Multiform

A PHASE II CLINICAL TRIAL FOR THE EVALUATION OF THE EFFICACY OF DISULFIRAM/COPPER COMBINATION AS AN ADJUVANT AND CONCURRENT CHEMOTHERAPY IN THE TREATMENT OF NEWLY DIAGNOSED GLIOBLASTOMA MULTIFORM

Petros Karamanakos, MD, PhD

Neurosurgeon, MD, PhD

University of Ioannina

University of Eastern Finland

University of Ulm

Two of the oldest individuals (a male and a female greater than 18 years of age) from each of 10-15 nonsmoking households from the high-risk region of Linxian, China

Esophageal Cancer

Chinese Academy of Medical Sciences

Environmental and Biological Monitoring Pilot Study for Polycyclic Aromatic Hydrocarbons in Linxian, China

To assess the association of PAHs and acetaldehyde with the high rate of esophageal cancer in Linxian, China, we plant to analyze samples of food for the presence of PAHs, ethanol and acetaldehyde,samples of blood for Hb and DNA adducts( markers of longterm PAH or acetaldehyde exposure), samples of urine for 1-OH-Pyrene glucuronide (a marker of short term PAH exposure) samples of salivafor acetaldehyde and samples of coal for characteristics that may be associated with increased carcinogenesis. We will also administer environmental questionnaires that will include questions about the type of fuel used for cooking and heating, the location and types of stove and /or heating units, and the time spent cooking.

National Cancer Institute (NCI)

acetaldehyde

kanker

neoplasms

acetaldehyde/kanker

Determination of ALDH1b1 and ALDH2 Polymorphisms Frequency in the Brazilian Population

L-cysteine Prevents Stomach Exposure to Carcinogenic Acetaldehyde

Disulfiram/Copper Combination In The Treatment of Newly Diagnosed Glioblastoma Multiform

Environmental and Biological Monitoring Pilot Study for Polycyclic Aromatic Hydrocarbons in Linxian, China

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