30 obese patients (12 M/ 18 F) with a mean BMI of 46 candidate to SG Alcohol drink mean volume: 158 Ml administered in 10 minutes

Alcohol Metabolism Modifier Adverse Reaction

Bariatric Surgery Candidate

Sleeve Gastrectomy

University of Rome "la sapienza"

Alcohol Metabolism After Sleeve Gastrectomy

Prospective Pathophysiological Evaluation of Alcohol Intake and Metabolism After Sleeve Gastrectomy

change in alcohol metabolite (ethanol and acetaldehyde) after SG

change in alcohol preferences measured with AUDIT( Alcol Use disorders Identification TesT) test

Angelo Iossa

principal investigator

University of Roma La Sapienza

Azienda vinicola Casal del Giglio

Daidzin 80 mg, single dose, oral administration (4 capsules of Super-Absorbable Soy Isoflavones®).
Alcohol 0.5 g/kg (vodka diluted in lemon-flavoured water), single dose, oral administration. Solution of 150 ml.

Alcohol 0.5 g/kg (vodka diluted in lemon-flavoured water), single dose, oral administration. Solution of 150 ml.

Healthy

Super-Absorbable Soy Isoflavones, LifeExtension, USA. Single oral dose of 4 capsules (containing 80 mg of daidzin-daidzein).

Daidzin

Alcohol

Parc de Salut Mar.

Interaction Between a Natural Aldehyde Dehydrogenase 2 (ALDH2) Inhibitor and Alcohol

Human Pharmacology Study to Evaluate the Interaction Between a Natural Inhibitor of Aldehyde Dehydrogenase 2 (ALDH2) and Alcohol in Healthy Volunteers. Pilot Clinical Trial

Calculation of AUC for blood alcohol concentrations

Vital signs (heart rate, blood pressure, respiration rate, oral and facial temperature) and adverse effects measured by visual analogue scales (nausea, vomiting, vertigo, dizziness, headache, breathing difficulty, facial flushing)

Drunkenness and euphoria will be measured by a visual analogue scale (VAS).

Calculation of AUC of plasmatic concentrations of daidzein, genistein and equol

Collection of adverse events spontaneously reported by the participants and/or observed by the investigators.

Subjective effects will be measured with the Addiction Research Center Inventory (ARCI)

Calculation of elimination half-life from blood ethanol concentrations

Calculation of elimination half-life of plasmatic concentrations of daidzein, genistein and equol

Urine will be collected in the following periods:0-2h,2-8h,8-14h,14-24 h after administration. Concentrations of daidzein, genistein and equol will be measured

acetaldehyde/muntah

Alcohol Metabolism After Sleeve Gastrectomy

Interaction Between a Natural Aldehyde Dehydrogenase 2 (ALDH2) Inhibitor and Alcohol

Effect of Glutathione on Blood Alcohol and Hangover Symptoms

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