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Substituted benzylidene indenyl formamides, acetamides and propionamides
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TECHNICAL FIELD
This invention relates to compounds and methods for treatment or prevention of precancerous lesions.
BACKGROUND OF THE INVENTION
Each year in the United States alone, untold numbers of people develop precancerous lesions. These lesions exhibit a strong tendency to develop into
Substituted benzylidene indenyl formamides, acetamides and propionamides
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TECHNICAL FIELD
This invention relates to compounds and methods for treatment or prevention of precancerous lesions.
BACKGROUND OF THE INVENTION
Each year in the United States alone, untold numbers of people develop precancerous lesions. These lesions exhibit a strong tendency to develop into
2-[1H-benzimidazol-2(3H)-ylidene]-2-(pyrimidin-2-yl)acetamides and 2-[benzothiazol-2(3H)-ylidene]-2-(pyrimidin-2-yl)acetamides as kinase inhibitors
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to 2-[1H-benzimidazol-2(3H)-ylidene]-2-(pyrimidin-2-yl)acetamides and 2-[benzothiazol-2(3H)-ylidene]-2-(pyrimidin-2-yl)acetamides, their salts, pharmaceutical compositions containing them, and their use as kinase inhibitors
N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,- 3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide, a dual modulator of chemokine receptor activity, crystalline forms and processes
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FIELD OF THE INVENTION
The present invention provides N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1- ,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide, or a pharmaceutically acceptable salt, solvate or prodrug, thereof, having unexpected desirable dual
N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-A][1,- 3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide, a dual modulator of chemokine receptor activity, crystalline forms and processes
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FIELD OF THE INVENTION
The present invention provides N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1- ,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide, or a pharmaceutically acceptable salt, solvate or prodrug, thereof, having unexpected desirable dual
N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-A][1,- 3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide, a dual modulator of chemokine receptor activity, crystalline forms and processes
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FIELD OF THE INVENTION
The present invention provides N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1- ,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide, or a pharmaceutically acceptable salt, solvate or prodrug, thereof, having unexpected desirable dual
N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-2-oxo-3-(6-(trifluoromethyl)quina- zolin-4-ylamino) pyrrolidin-1-yl)cyclohexyl)acetamide and other modulators of chemokine receptor activity, crystalline forms and process
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STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPED
Not Applicable
THE NAMES OF THE PARTIES TO A JOINT RESEARCH AGREEMENT
Not Applicable
INCORPORATION-BY-REFERENCE OF MATERIAL SUBMITTED ON A COMPACT DISC
Not Applicable
BACKGROUND OF THE INVENTION
(1) Field of the Invention
The present
2-(1h-indol-3-yl)-2-oxo-acetamides with antitumor activity
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The present invention relates to 2-(1H-indol-3-yl)-2-oxo-acetamides having antitumor activity, particularly against solid tumors, more precisely colon and lung tumors.
Colo-rectal carcinoma is one of the most common tumors in Western countries as it accounts for about 421,000 new cases each year in
Substituted heteroaryl- and aryl-cyclopropylamine acetamides and their use
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CROSS-REFERENCE TO RELATED PATENT APPLICATIONS
This application is the U.S. National Phase of PCT/EP2010/055103, filed Apr. 19, 2010, which claims priority to European Patent Application 09172705.7, filed Oct. 9, 2009, which is incorporated herein by reference in entirety.
FIELD OF THE INVENTION
The
2-piperidin-1-yl-acetamide compounds for use as tankyrase inhibitors
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FIELD OF THE INVENTION
The present invention relates to novel 2-piperidin-1-yl-acetamide compounds, pharmaceutical compositions containing them, and the use of such compounds as tankyrase inhibitors and in the treatment of Wnt signaling and tankyrase 1 and 2 signaling related disorders which
Substituted condensation products of n-benzyl-3-indenyl acetamides with heterocyclic aldehydes
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TECHNICAL FIELD
This invention relates to compounds and methods for inducing or promoting apotosis and for arresting uncontrolled neoplastic cell proliferation, methods that are specifically useful in the arresting and treatment of neoplasias, including precancerous and cancerous lesions.
BACKGROUND
N-pyridinyl acetamide derivatives as Wnt signalling pathway inhibitors
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RELATED APPLICATIONS
This application is a .sctn. 371 national stage application based on Patent Cooperation Treaty Application serial number PCT/GB2015/052943, filed Oct. 8, 2015; which claims the benefit of priority to GB 1417832.1, filed Oct. 8, 2014; and GB 1512279.9, filed Jul. 14, 2015.
This
N-pyridinyl acetamide derivatives as inhibitors of the Wnt signaling pathway
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RELATED APPLICATIONS
This application is a .sctn. 371 national stage application based on Patent Cooperation Treaty Application serial number PCT/GB2015/052939, filed Oct. 8, 2015; which claims the benefit of priority to GB 1417829.7, filed Oct. 8, 2014; and GB 1511387.1, filed Jun. 29, 2015.
This
Pharmaceutical combination of MEK inhibitor and B-RAF inhibitors
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FIELD OF THE INVENTION
The present invention relates to a method of treating cancer in a mammal and to combinations useful in such treatment. In particular, the method relates to a novel combination comprising the MEK inhibitor
Materials and methods for sensitizing multidrug resistant cells
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FIELD OF INVENTION
This disclosure is related to materials and methods for sensitizing multidrug resistant cancer cells to various chemotherapeutic reagents by supply compounds that reduce the activity of various ATP binding cassette (ABC) transporters.
BACKGROUND
Multidrug resistance (MDR) is a
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