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FIGHT-RP 1 Extension Study

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The Combination of Atorvastatin, Acetylcysteine and Danazol as the Treatment of Steroid-resistant/Relapse Immune Thrombocytopenia

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Immune thrombocytopenia (ITP) is a severe bleeding disorder. Approximately 2/3 of patients achieve remission from first-line therapies. However, the underlying mechanism of corticosteroid-resistant or relapsed ITP is not well understood; thus, treatment remains a great challenge. Atorvastatin was

Identification of Host Factors of Norovirus Infections in Mini-Gut Model

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Study design and overview - This is a laboratory-based study. The investigators plan to establish a list of host cellular proteins regulating norovirus infection. Methods will include establishment of patient-specific stem cell-derived human intestinal enteroids as an infection model and genome-wide

A Safety and Efficacy Study of NAC in Patients With TA-TMA

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Hematopoietic stem cell transplantation (HSCT) has been commonly used as a potentially curative option in the treatment of various hematological malignancies. However, it may end up with serious complications in various systems, including the hemostatic system. HSCT associated thrombotic

Comparison of Bovine Colostrum Versus Placebo in Treatment of Severe Alcoholic Hepatitis: A Randomized Double Blind Controlled Trial

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Diagnosis: The diagnosis of Alcoholic hepatitis is made by the following criteria (12) I. Chronic active alcohol abuse - >80 grams in males and > 60 grams in females for > 5 years for developing Alcoholic Cirrhosis (13) Alcohol use will be evaluated with the AUDIT score (EASL guidelines (14) II.

Efficacy of Combination Therapy of Glucocorticoids and Bovine Colostrum in Treatment of Severe Alcoholic Hepatitis.

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Severe alcoholic hepatitis is associated with significant morbidity and mortality. Diagnosis: The diagnosis of (AH) is made by the following criteria11 I.Chronic active alcohol abuse - > 80 grams in males and > 20 grams in females. II. Duration of jaundice < 3 months III. Serum Bilirubin >5 mg/dl

Methylprednisolone N Acetylcysteine in Hepatic Resections

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Elective liver resection is performed mainly for benign and malignant liver tumors. The malignant tumors may arise primarily within the liver (hepatocellular carcinoma and cholangiocarcinoma) or represent metastases from malignancies of other organs. During hepatic resection, the risk of severe

Mechanisms of N-acetylcysteine Mediated Vascular Adverse Effects

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In this study the investigators test the following hypotheses: 1. NAC causes dose-dependent vasodilatation associated with histamine release in vivo. 2. Release of other mediators, known to be associated with anaphylaxis, does not occur during anaphylactoid reactions to NAC. 3. Paracetamol has a

N-Acetylcysteine in Severe Acute Alcoholic Hepatitis

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Acetaminophen in aSAH to Inhibit Lipid Peroxidation and Cerebral Vasospasm

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Aneurysmal subarachnoid hemorrhage (aSAH) is an often devastating form of stroke with high morbidity and mortality despite advances in surgical management. Approximately 30,000 patients annually suffer aSAH in the U.S. For patients who survive the initial subarachnoid hemorrhage, delayed cerebral

Pilot Study of a Multi-Drug Regimen for Severe Pulmonary Fibrosis in Hermansky-Pudlak Syndrome

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Hermansky-Pudlak Syndrome (HPS) is a rare autosomal recessive disease consisting of oculocutaneous albinism and a platelet storage pool defect. The most serious complication of this disorder, pulmonary fibrosis, occurs only in genetic subtypes HPS-1 and HPS-4 and is generally fatal in the fourth or

N-acetylcysteine in Intra-amniotic Infection/Inflammation

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Despite extensive research, the etiology of most preterm births remains unknown. There are significant fetal consequences associated with preterm birth, which include necrotizing enterocolitis, fetal respiratory distress and intra-ventricular hemorrhage. Perinatal mortality is about 44%, 11% and 5%

Comparison of Two Different Doses of Paracetamol for Post-Operative Pain Relief

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A randomised, crossover dose-effect trial of paracetamol 60 and 90 mg/kg in third molar surgery Background Paracetamol is the most widely used analgesic in New Zealand but relatively little is known about its dose effect and concentration effect relationships. It appears that there is greater effect

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