adriamycin/demam

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Improving efficiency of adriamycin crossing blood brain barrier by combination of thermosensitive liposomes and hyperthermia.

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Adriamycin (ADM)-encapsulated thermosensitive liposomes (ts-lip-ADM) and common liposomes (lip-ADM) were developed and evaluated. The encapsulation efficiency of the two liposomes were above 99%, and the average sizes of liposomes were about 120 nm. Temperature-dependent drug release from loaded

Modulation of adriamycin cytotoxicity and transport in drug-sensitive and multidrug-resistant Chinese hamster ovary cells by hyperthermia and cyclosporin A.

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OBJECTIVE Chemosensitizers such as cyclosporin A can increase intracellular accumulation of chemotherapeutic agents such as Adriamycin in certain multidrug-resistant (MDR) cell lines with overexpression of P-glycoprotein. It is likely that, when combined with cyclosporin A, hyperthermia could

Effect of hyperthermia, radiation and adriamycin combinations on tumor vascular function.

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Pathophysiologic studies of tumor vascular responses to hyperthermia, radiation or adriamycin given alone or in specific combinations have been made in the cervical carcinoma grown in the transparent cheek pouch chamber of the Syrian hamster. A specially designed chamber containing a compartment for

In vitro action of continuous-wave ultrasound combined with adriamycin, X rays or hyperthermia.

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We compared the ability of continuous-wave ultrasound to enhance cytotoxicity from X irradiation, hyperthermia or exposure to adriamycin. The survival of CHO cells exposed in culture medium to these agents was determined with and without continuous-wave ultrasound (1.62 or 1.765 MHz). In

In vitro modulation of adriamycin and mitoxantrone cytotoxicity by hyperthermia and diazepam, in human chronic myeloid leukemia cells.

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Adriamycin and mitoxantrone are known antitumor agents. The use of these agents is limited by their toxicity to normal body tissue. This paper shows that it is possible to achieve greater log cell-kill by using these drugs in combination with hyperthermia and diazepam. Experiments were carried out

[Adriamycin combined with hyperthermia inhibits transplanted B cell lymphoma in nude mice].

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OBJECTIVE To study the effect of adriamycin combined with hyperthermia on tumor formation and growth of human B lymphoma cell line (Raji) in nude mice. METHODS Twenty-four BALB/C nude mice were divided into control group (37 degrees celsius;), chemotherapy group (37 degrees celsius;+ADM),

Intracellular uptake, retention and cytotoxic effect of adriamycin combined with hyperthermia in vitro.

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The intracellular uptake, retention and cytotoxic effect of adriamycin (ADR) were investigated by a flow cytometry technique with NIH 3T3 cells. The intracellular uptake and cytotoxic effect of ADR increased as a function of exposure time and external drug concentration at 37 degrees. A good

Distribution of adriamycin in mice under conditions of local hyperthermia which improve systemic drug therapy.

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Local tumor hyperthermia (LTH) (43 degrees C for 60 minutes) enhanced the effectiveness of Adriamycin (ADR) (10 mg/kg iv) administered systemically against the 16C mouse mammary adenocarcinoma. LTH was produced by the local application of 2450 MHz microwaves to sc implanted tumors. During LTH the

Adriamycin combined with hyperthermia and dipyridamole is cytotoxic both in vitro and in vivo.

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The cytotoxicity of adriamycin (ADM) combined with hyperthermia (Hyp) and/or dipyridamole (DP) was investigated using B16 melanoma cells in vitro and in vivo. When ADM was combined with Hyp at 43 degrees C or DP in a dose of 5 microM or with both, drug cytotoxicity enhanced the inhibition of colony

Kinetic and survival response of the M14 cell line to lonidamine associated with adriamycin or hyperthermia.

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Lonidamine (LND), an indazole-carboxylic acid derivative, was delivered alone and together with adriamycin (ADM) or hyperthermia to the human melanoma cell line M14, and cell survival was assessed. Cell cycle-specific effects were investigated by analyzing sequences of DNA content histograms by

Effect of hypothermia and hyperthermia on the induction of chromosome aberrations by adriamycin in human leukocytes.

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When human leukocytes are treated with adriamycin (ADR) for brief durations of 1 to 2 hr at concentrations ranging between 0.04 and 0.25 microgram/ml, a dramatic reduction is observed in the frequency of chromosome aberrations in cells treated at 4 degrees in comparison to those treated at 37

Effects of hyperthermia and cepharanthin on adriamycin accumulation with changes in extracellular pH.

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We compared adriamycin (ADR) accumulation with the intensity of intracellular fluorescence of 3,3'-(di-n-hexyl)-2,2'-oxacarbocyanine iodide (NK-2280), an indicator of cell membrane potential, after hyperthermia and examined the effects of cepharanthin (CEP) on the accumulation of ADR and NK-2280 in

Enhanced effectiveness of adriamycin and bleomycin combined with local hyperthermia in neck node metastases from head and neck cancers.

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The results of this study concern the comparison of the clinical effects of adriamycin (ADM) or bleomycin (BLM) alone and combined with local hyperthermia on 15 patients with multiple (29) neck node metastases from head and neck cancers. With repeated low fractional daily doses of drug a significant

Modification of thermosensitivity and chemosensitivity induced by combined treatments with hyperthermia and adriamycin.

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Both adriamycin (ADM) and hyperthermia show thermal chemo-enhancement. Tolerance induction against ADM in heated cells has been reported resulting in clinical difficulty of cancer therapy. We investigated thermo-enhancement induced with ADM (0.2 microg/ml) treatment alone or combined with ADM and 42

Effects of adriamycin and hyperthermia on cellular uptake of [3H]thymidine and its significance for the incorporation into DNA.

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Inhibition of the salvage DNA synthesis was studied in ascites tumour cells up to 240 min at moderately increased temperatures of 39 degrees C, 40.5 degrees C and 43 degrees C alone or in combination with adriamycin (ADR). Hyperthermia and ADR acted additively on salvage DNA synthesis. The

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