high dose PPI induction (oral rabeprazole 20mg qid) for 3 days, then 14 days combined with amoxicillin (regular dose, daily 2 g, 500mg qid) for high frequency dual therapy.

conventional triple therapy 14 days (rabeprazole 20 mg bid, amoxicillin 1 g bid, clarithromycin 500 mg bid)

high dose PPI (oral rabeprazole 20mg qid) induction for 3 days, then Rabeprazole 20 mg qid, amoxicillin 500 mg qid, levofloxacin 500 mg qd for 14 days.

levofloxacin base rescue therapy 14 days (rabeprazole 20 mg bid, amoxicillin 1 g bid, levofloxacin 500 mg qd)

Helicobacter Pylori Infection

Helicobacter Gastritis

Helicobacter-Associated Pyloric Ulcer

Rabeprazole daily four time (Bid) or daily four times (Qid) Amoxicillin used daily two times (1000 mg bid) or daily four times (500 mg qid) apply in the first line or the second line H pylori eradication therapy

Rabeprazole

Chang-Gung memorial hospital at Keelung

Daily Four Times or Two Times Usage of PPI and Amoxicillin for the First or Second Line H. Pylori Eradication

A Comparison Study of Helicobacter Pylori Eradication Rates Between Daily Four Times and Daily Two Times Usage of Proton Pump Inhibitor and Amoxicillin for the First Line and the Second Line Eradication Therapy

Two to three months after eradication therapy, urea breath test will be performed. If the result of UBT is negative, it means successful eradication. If the result is positive, it means eradicaiton failure

Li-Wei Chen

chief, division of hepato-gastroenterology

Chang Gung Memorial Hospital

This group received triple standard therapy with standard doses of omeprazole. 20 mg "omeprazole" before breakfast and before dinner. 500 mg "clarithromycin" after breakfast and after dinner and 1 g "amoxicillin" after breakfast and after dinner for 10 days.

This group received triple standard therapy, using 500 mg "clarithromycin" after breakfast and after dinner and 1 g "amoxicillin" after breakfast and after dinner for 10 days in addition with "omeprazole" but "omeprazole" doses were prescribed according to CYP2C19 genotype as a follows: a) Patients with CYP2C19 *1/*1 genotype (Early and ultrarapid Metabolizer): 40mg "omeprazole" before breakfast and before dinner. b) Patients with CYP2C19 *1/*2 or *1/*3 genotype (Intermediate Metabolizer): 20mg "omeprazole" before breakfast, 20mg before lunch and 20mg before dinner. c) Patients with CYP2C19 *2/*2 (Poor Metabolizer): 20mg "omeprazole" before breakfast and 20 mg before dinner.

CYP2C19 Polymorphism

H.Pylori Infection

Therapy

Patients in this received triple standard therapy for eradication of H.pylori with standard doses of proton pump inhibitor (omeprazole), in combination with amoxicillin and clarithromycin in absence of antibiotic resistance.

amoxicillin clarithromycin omeprazole 1

The treatment for patients in this group was prescribing triple standard therapy for H.pylori eradication with amoxicillin and clarithromycin in absence of antibiotic resistance but with different doses of proton pump inhibitor (omeprazole) according to CYP2C19 genotype in each patients.

amoxicillin clarithromycin omeprazole 2

Efficacy of First-Line Helicobacter pylori Eradication Treatment With Two Triple Regimens With Levofloxacin

CYP2C19 Genotypes and Future Applications in Personalized Therapies for Helicobacter pylori Eradication

Personalized Therapy for Helicobacter pylori Eradication Depending on CYP2C19 Polymorphisms

Effect of the CYP2C19 Polymorphism in Helicobacter Pylori Eradication

Azucena Arévalo Galvis, MSc

Bacteriologist

Javeriana University

Universidad Nacional de Colombia

A randomized single - blinded Clinical Trial conducted from 2012 to 2015 in Bogotá, Colombia. The aim was studying the effectiveness of triple therapy for H. pylori with amoxicillin, clarithromycin and standard dose of omeprazole versus amoxicillin, clarithromycin with dose of omeprazole according to CYP2C19 polymorphisms was studied, the subjects were allocated to a treatment regimen according to a randomized crossover sequence, provided by a computer-generated randomization list. Patients were contacted by telephone for assigned an appointment for treatment delivery according to the assigned group.

The mean masking was the treating Gastroenterologist doctor.

MCSE group: 1 ml of 0.25% bupivacaine will be injected intrathecally

Dural puncture performed with a spinal needle, but no medication will be injected intrathecally.

To Determine the Onset of Analgesia (Numerical Rating Scale for Pain = 1) in Minutes

Modified CSE

DPE group: Dural puncture performed, but no medication will be injected intrathecally.

Dural puncture epidural

Comparison of Labor Analgesia Between Modified Combined Spinal-Epidural and Dural Puncture Epidural Techniques

Comparing the Quality of Labor Analgesia Between Modified Combined Spinal-Epidural and Dural Puncture Epidural Techniques: A Randomized Double Blinded Clinical Trial

Numerical Rating Scale (NRS) for pain </= 1/10 in minutes

Time to T10 sensory block in minutes will be measured

Participants will be assessed for pruritus every hour, by grading the severity on a scale ranging from 0-3; 0 = none, 1 = mild, 2= moderate and 3 = severe

Fetal bradycardia is defined as a fetal heart rate of less than 100 beats per minute, persisting for more than 1 minute.

Western University, Canada

Patients with Helicobacter pylori in biopsy, cultures will be obtained and subsequently sensitivity to antibiotics studied.

Abdominal Pain

Children

Bacterial Infection Due to Helicobacter Pylori (H. Pylori)

Antibiotic Resistant Strain

Biopsy specimens for histology will be fixed in formalin, embedded in paraffin and sectioned and stained with hematoxylin and eosin.
The microbiological workup will include an imprint of the biopsy on a slide followed by a gram stain for the purpose of demonstrating H. pylori in situ. Further the biopsies will be streaked out on chocolate agar, Sheep blood agar and H. pylori selective agar supplemented with Polymixin to suppress possible contaminants.
4 days of incubation in a micro aerophilic atmosphere will follow . Susceptibility testing of H pylori will be performed with E test on Mueller Hinton agar supplemented with defibrinated sheep blood using a MacFalrland 3.0 density of a bacterial suspension. Reading the susceptibility will take place following 72 hours of incubation in a micro aerophilic atmosphere.

Helicobacter Pylori Culture

Ha'Emek Medical Center

Resistance of Helicobacter Pylori to Antibiotics in Children

Dr Koren Ariel

Head of Pediatric Dpt B

HaEmek Medical Center, Israel

Diarrhea

Constipation

probiotics (antibiophilus(Lactobacillus casei), bio-three) 4x 10^8CFU/day

probiotics (antibiophilus(Lactobacillus casei), bio-three)

Effect of Probiotics on Intestinal Bacterial Population and Immune Modulation

Phase 4 Study of Probiotics on Intestinal Bacterial Population and Immune Modulation

secondary outcome including body weight change, appetite and daily intake, bloating or abdominal distension, abdominal pain or colic, constipation, fever, and vomiting were also assessed. IgA levels and bacterial culture were performed on homogenized fecal samples. Fecal lactoferrin and calprotectin levels were measured with samples of feces.

agar/muntah

Daily Four Times or Two Times Usage of PPI and Amoxicillin for the First or Second Line H. Pylori Eradication

Effect of the CYP2C19 Polymorphism in Helicobacter Pylori Eradication

Comparison of Labor Analgesia Between Modified Combined Spinal-Epidural and Dural Puncture Epidural Techniques

Resistance of Helicobacter Pylori to Antibiotics in Children

Effect of Probiotics on Intestinal Bacterial Population and Immune Modulation

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