The present invention provides a method of screening for the presence or absence of cancer characterized by increased DNA synthesis. The present invention also provides a method of monitoring the effectiveness of treatment of cancer characterized by increased DNA synthesis. The methods are based on the observation that increased de novo pyrimidine biosynthesis is characteristic of malignant solid tumors. An initial step of pyrimidine biosynthesis is the conversion of orotidine monophosphate (OMP) to uridine monophosphate by OMP decarboxylase which is inhibited by mononucleotide precursors such as 6-hydroxyuridine, 6-azauridine, uridine, allopurinol and oxipurinol. Inhibition of OMP decarboxylase results in accumulation of orotidine and orotate which can be measured in a urine sample. The accumulation of oritidine and orotate, in amounts above that of a control, provides an indicator that the subject has a cancer characterized by having increased DNA synthesis.

Brusilow Enterprise LLC

Use of orotidine monophosphate decarboxylase inhibition in a method for cancer screening

A composition and method for the treatment of the side-effects associated with the administration of cancer chemotherapeutic agents involves the oral ingestion of a slow release capsule containing adenine and orotate. The administration of a protein pump inhibitor decreases systemic absorption of orotate and the administration of allopurinol decreases the formation of 2,8-dihydroxy adenine from adenine. In an alternative embodiment, cationic liposomes contain purine/pyrimidine precursors. The cationic liposomes bind to the cells lining the mucosa of the intestinal tract and then the contents of the cationic liposome are then taken up in the interior of the cells to prevent the metabolism of the cancer treatment drug 5-FU into a toxic species.

Ford; John P.

allopurinol/kanker

Use of orotidine monophosphate decarboxylase inhibition in a method for cancer screening

Compositions and methods for treatment of the side-effects associated with administration of cancer chemotherapeutic agents

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