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allopurinol/seizures
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Allopurinol does not affect the anticonvulsant activity of carbamazepine and valproate in maximal electroshock-induced convulsions in mice.
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Allopurinol, an inhibitor of xanthine oxidase, is indicated in the management of patients with elevated serum and urinary uric acid levels. It was also reported to be beneficial in patients with epilepsy when added to traditional antiepileptic drug. Here, we investigated the effect of allopurinol
Allopurinol-induced arteritis in partial HGPRTase deficiency. Atypical seizure manifestation.
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A 17-year-old boy with partial hypoxanthine-guanine phosphoribosyl transferase deficiency developed a hypersensitivity reaction to allopurinol. The reaction was manifested by the development of bizarre, atypical seizures. The patient had been neurologically normal prior to the reaction. Seizures
The effect of allopurinol on oxygen-induced seizures in mice.
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Prolonged exposure to hyperbaric oxygen causes central nervous system (CNS) oxygen toxicity manifested by grand mal seizures. The superoxide anion is believed to be a cause of tissue damage in CNS oxygen toxicity and it is proposed that xanthine oxidase activity is one of the prime sources of
Anticonvulsant effect of allopurinol on hippocampal-kindled seizures.
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This study assessed the anticonvulsant effect of allopurinol (5 and 50 mg/kg, IP) on seizures kindled from the feline hippocampus. Allopurinol at a higher dose significantly reduced the behavioral seizures stage, but not afterdischarge duration, without producing any behavioral toxicity. The present
Allopurinol add-on treatment in intractable seizures.
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Recent reports in clinical literature have suggested an antiepileptic effect of the xanthine oxidase inhibitor Allopurinol (ALL) when added to traditional drugs. However, other reports have failed to confirm beneficial effects of this drug. In view of these conflicting results, we have carried out a
Reversal of organic brain syndrome with seizures and hyperuricosuria subsequent to allopurinol therapy.
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Progressive seizures with hyperuricosuria reversed by allopurinol.
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Allopurinol may prolong seizure duration on electroconvulsive therapy: a case report.
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An assessment of the possible protective effect of allopurinol in acute stroke.
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Allopurinol has been shown to have a protective effect on ischaemic tissue by the indirect prevention of excessive purine loss. This property was tested in the gerbil model of acute stroke. A total of 69 animals were pretreated with an intraperitoneal injection of either allopurinol (50 mg/kg) or
Effect of piperonyl butoxide or allopurinol on cyanide-induced lipid peroxidation in mouse brain.
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The effect of piperonyl butoxide or allopurinol on cyanide-induced lipid peroxidation was investigated using homogenates from whole brain of mice. The brain homogenate exposed to a low concentration of potassium cyanide (10, 50, or 100 microM) was significantly increased in their concentration of
[Allopurinol in the combined therapy of severe forms of epilepsy in children].
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Allopurinol was tested as an antiepileptic drug (AED) in children with progressive history of the disease, frequent severe seizures and ineffective conventional AED treatment. A total of 38 children aged 4 months to 10 years were given allopurinol at daily doses of 4 to 5 mg/kg body weight. The drug
Double-blind, placebo-controlled, cross-over trial of allopurinol as add-on therapy in childhood refractory epilepsy.
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We report the results of a double-blind, placebo-controlled cross-over trial with allopurinol as add-on therapy in childhood refractory epilepsy. Seventeen patients received allopurinol and matched placebo for 12 weeks in 2 doses (10 mg/kg/day during the first week and 15 mg/kg/day thereafter with a
Allopurinol and severe epilepsy.
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Forty-one epileptic and not hyperuricemic subjects, aged 2 to 54 years, had epileptic seizures, ranging from 1 to 220 weekly (mean = 21.3). All seizure types were represented. They were already medicated with two or three antiepileptic drugs with plasma drug concentrations maintained in therapeutic
Allopurinol as an add-on drug in the management of intractable epilepsy.
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The efficacy of allopurinol as an antiepileptic drug has been assessed in a 12 week add-on open uncontrolled study in a small series of 12 patients with intractable epilepsy. Weekly seizure frequencies were observed to be reduced in 4 patients and increased in 5 patients but these changes were not
Allopurinol in severe epilepsy. A preliminary report.
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We have studied 64 epileptic subjects aged 2-54 years. The subjects were not hyperuricemic and presented daily or weekly severe seizures not controlled by optimal therapy with antiepileptic drugs maintained at 'therapeutic' plasma concentrations. Allopurinol at doses ranging from 150 to 300 mg daily
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