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alpha carotene/kanker payudara
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Effect of a carotene concentrate on the growth of human breast cancer cells and pS2 gene expression.
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Breast cancer is the most common cancer in women worldwide. The growth of breast cancer cells is either hormone-dependent or hormone-independent. Both types are represented in vitro by the estrogen-receptor positive (ER+) MCF-7 and the estrogen-receptor negative (ER-) MDA-MB-231 cell lines,
Plasma carotenoids and breast cancer risk in the Cancer Prevention Study II Nutrition Cohort.
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OBJECTIVE
Several circulating carotenoids have been inversely associated with postmenopausal breast cancer risk in large cohort studies and a pooled analysis. Whether associations differ by tumor or participant characteristics remains unclear. We investigated the associations of plasma carotenoids
Carotenoids, alpha-tocopherols, and retinol in plasma and breast cancer risk in northern Sweden.
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OBJECTIVE
Using a nested case-referent design we evaluated the relationship between plasma levels of six carotenoids, alpha-tocopherol, and retinol, sampled before diagnosis, and later breast cancer risk.
METHODS
In total, 201 cases and 290 referents were selected from three population-based cohorts
Circulating carotenoids, mammographic density, and subsequent risk of breast cancer.
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Mammographic density is one of the strongest predictors of breast cancer risk. Recently, it has been suggested that reactive oxygen species may influence breast cancer risk through its influence on mammographic density. In the current study, we addressed this hypothesis and also assessed if the
Plasma carotenoids, retinol, and tocopherols and risk of breast cancer.
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The roles of carotenoids, retinol, and tocopherols in breast cancer etiology have been inconclusive. The authors prospectively assessed the relations between plasma alpha-carotene, beta-carotene, beta-cryptoxanthin, lycopene, lutein/zeaxanthin, retinol, alpha-tocopherol, and gamma-tocopherol and
Dietary carotenoids and risk of breast cancer in Chinese women.
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There has been considerable interest in the role of carotenoids in the chemoprevention of cancer. However, the protective effect of carotenoids on breast cancer has been inconclusive. To investigate whether intake of lycopene, alpha-carotene, beta-carotene, beta-cryptoxanthin, and lutein/zeaxanthin
Carotenoids, retinol, and vitamin E and risk of proliferative benign breast disease and breast cancer.
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We investigated the relationship between serum levels of retinol, beta-carotene, alpha-carotene, lycopene, alpha-tocopherol, and gamma-tocopherol as well as intakes of retinol, carotene, and vitamin E and the risks of breast cancer and proliferative benign breast disease (BBD) in a case-control
Plasma carotenoid- and retinol-weighted multi-SNP scores and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium.
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BACKGROUND
Dietary and circulating carotenoids have been inversely associated with breast cancer risk, but observed associations may be due to confounding. Single-nucleotide polymorphisms (SNPs) in β-carotene 15,15'-monooxygenase 1 (BCMO1), a gene encoding the enzyme involved in the first step of
Prospective study of carotenoids, tocopherols, and retinoid concentrations and the risk of breast cancer.
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Previous prospective studies have raised the possibility that the antioxidantproperties of carotenoids and vitamin E (alpha-tocopherol) and the role of vitamin A (retinol) in cellular differentiation may be associated with a reduced risk of subsequent breast cancer. To investigate the association
[Nutrition and female breast tumors].
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This review presents current knowledge of diet and breast cancer. In the first part it reviews current knowledge of nutritional risk factors. Obesity, total energy intake, intake of saturated fatty acids and alcohol were considered as high risk factors for breast cancer in the past. In addition to
A prospective study of XRCC1 haplotypes and their interaction with plasma carotenoids on breast cancer risk.
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The XRCC1 protein is involved in the base excision repair pathway through interactions with other proteins. Polymorphisms in the XRCC1 gene may lead to variation in repair proficiency and confer inherited predisposition to cancer. We prospectively assessed the associations between polymorphisms and
Breast cancer and dietary and plasma concentrations of carotenoids and vitamin A.
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A case-control study of breast cancer was conducted in Buffalo. Participants completed a food frequency questionnaire and donated a fasting blood sample before definitive workup for breast masses. Dietary and plasma concentrations of carotenoids and retinol for 83 women found to have breast cancer
MGMT genotype modulates the associations between cigarette smoking, dietary antioxidants and breast cancer risk.
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O(6)-methylguanine DNA methyl-transferase (MGMT) is the only known critical gene involved in cellular defense against alkylating agents in the DNA direct reversal repair (DRR) pathway. Three single nucleotide polymorphism (SNP) coding for non-conservative amino acid substitutions have been
Premenopausal breast cancer risk and intake of vegetables, fruits, and related nutrients.
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BACKGROUND
Given the international variations in breast cancer incidence rates and the changes in breast cancer incidence among migrant populations, it has been hypothesized that diet is a factor influencing risk of this disease. Many studies indicate that a diet high in vegetables and fruits may
Intake of specific carotenoids and essential fatty acids and breast cancer risk in Montreal, Canada.
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BACKGROUND
Evidence from previous investigations into the possible role of dietary and serum carotenoid concentrations in the etiology of breast cancer is inconsistent. No study has examined the combined effect of carotenoids and essential fatty acids on the risk of breast cancer.
OBJECTIVE
The
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