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Halaman 1 dari 71 hasil
Behavioral and electrical correlates of absence seizures induced by thalamic stimulation in juvenile rhesus monkeys with frontal aluminum hydroxide implants: a pharmacologic evaluation.
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A new method for producing electro-clinical correlates of absence seizures (petit mal epilepsy) in conscious juvenile rhesus monkeys is described. A behavioral arrest reaction associated with concomitant 2 1/2 to 3 Hz spike and wave electroencephalograph (EEG) after discharge pattern, was obtained
Seizure and elevated blood aluminum in a remelt furnace operator: connection or coincidence?
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A simplified technique for producing aluminum hydroxide-induced chronic focal seizures in monkeys.
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The 3-hydroxypyridin-4-ones more effectively chelate aluminum in a rabbit model of aluminum intoxication than does desferrioxamine.
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This study was conducted to assess the influence of lipophilicity on the in vivo aluminum (Al) chelation activity of 3-hydroxypyridin-4-ones (HPs). Chelation activity was evidenced as increased Al elimination in an animal model of Al accumulation and toxicity. The subjects were Al-loaded rabbits. A
The early involvement of subcortical structures during the development of a cortical seizure focus.
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Cortical surface electrodes and bipolar depth electrodes were implanted stereotaxically in the ventral posterolateral and paracentral thalamic nuclei, amygdala, hippocampus, and putamen in adult cats to determine the progressive involvement of these structures in the generalization of an
Fatal encephalopathy after otoneurosurgery procedure with an aluminum-containing biomaterial.
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Refractory status epilepticus was observed in two patients who underwent vestibular neurectomy. We investigated the relationship with the use of an aluminum containing bone cement during the procedure. Two patients developed focal and thereafter generalized seizures in the late postoperative period
Evaluating Differences in Aluminum Exposure through Parenteral Nutrition in Neonatal Morbidities.
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Aluminum is a common contaminant in many components of parenteral nutrition, especially calcium and phosphate additives. Although long-term effects have been described in the literature, short-term effects are not well-known. Currently, the Food and Drug Administration recommends maintaining
Chronic model of neurofibrillary changes induced in mature rabbits by metallic aluminum.
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A slurry of aluminum powder injected into the brains of mature rabbits produced neurofibrillary changes in neurons of spinal cord and cerebrum similar to those produced by aluminum chloride, and with similar topography and rates of formation. The major difference observed with this preparation was
Aluminum chloride induced neurofibrillary changes in the developing rabbit a chronic animal model.
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Aluminum chloride injected into the brains of developing rabbits produced profound neurofibrillary changes to neurons of spinal cord and cerebrum similar to those produced in adult rabbits, along with a variety of clinical symptoms with the exception of seizures. Approximately half of the rabbits
Pharmacokinetics of aluminum 3-hydroxypyridin-4-one complexes: implications for aluminum redistribution subsequent to chelation therapy.
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The pharmacokinetics of selected aluminum-hydroxypyridinone (Al-HP complexes were determined in rats to better understand the relationship between their disposition and elimination parameters and the safety of HPs in the chelation therapy of Al intoxication. Five complexes were administered as i.v.
Ionic changes during experimentally induced seizure activity.
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Changes in intra- and extracellular ionic activity and their relation to generation and termination of seizure phenomena can be studied with the help of ion-selective microelectrodes. Transient changes in extracellular potassium activity (aK) of the cortex regularly accompany paroxysmal activity
Iron and aluminum in Alzheimer's disease.
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In this case presentation, a woman with high serum levels of aluminum was treated with chelation therapy with deferoxamine and ascorbic acid. This patient was initially bedridden and the clinical situation was complicated by epileptic seizures. After the chelation therapy, the clinical condition was
Studies of aluminum in rat brain.
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The effects of high aluminum concentrations in rat brain were studied using(14)C autoradiography to measure the uptake of [(14)C]2deoxy-D-glucose ([(14)C]2DG) and microbeam proteon-induced X-ray emission (microPIXE) with a 20-μm resolution to measure concentrations of magnesium, aluminum, potassium,
Accumulation of aluminum in a nondialyzed uremic child receiving aluminum hydroxide.
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A child with renal insufficiency was treated with the oral phosphate binder aluminum hydroxide from age 6 to 31 months. The prescribed dose of elemental aluminum varied from 31 to 108 mg/kg/d. Concurrently the patient developed vitamin D-resistant osteomalacia which failed to improve with
Autopsy case of aluminum encephalopathy.
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We report the case of a 59-year-old female aluminum encephalopathy patient who had chronic renal failure and took 3.0 g hydroxy-aluminum gel per day for the control of serum phosphorus level during a 15-year period. Nine months before her death she developed disorientation, memory disturbance,
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