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Halaman 1 dari 19 hasil
Use of the non-opiate analgesic drug flupirtine for the treatment of overactive bladder and associated diseases including urge incontinence, urinary flow problems as a result of prostate hyperplasia and irritable bowel syndrome
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This application claims priority from European Patent Application No. 05 001 967.8 filed Jan. 31, 2005, incorporated herein by reference in its entirety.
FIELD OF THE INVENTION
The present invention is directed to the prevention, reversal and medical treatment of lower urinary tract dysfunction
4-[aryl(8-azabicyclo[3.2.1]octan-3-yl)]aminobenzoic acid derivatives
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FIELD OF THE INVENTION
The present invention is directed to delta-opioid receptor modulators. More particularly, the present invention is directed to 4-[aryl(8-azabicyclo[3.2.1]octan-3-yl)]aminobenzoic acid derivatives which are delta-opioid receptor modulators useful as effective
Indole and benzothiazole derivatives
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Throughout this application, various references are referred to within parentheses. Disclosures of these publications in their entireties are hereby incorporated by reference into this application to describe more fully the state of the art to which this invention pertains.
BACKGROUND OF THE
Substituted indoles and uses thereof
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Throughout this application, various references are referred to within parentheses. Disclosures of these publications in their entireties are hereby incorporated by reference into this application to describe more fully the state of the art to which this invention pertains.
BACKGROUND OF THE
Substituted indoles and uses thereof
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Throughout this application, various references are referred to within parentheses. Disclosures of these publications in their entireties are hereby incorporated by reference into this application to describe more fully the state of the art to which this invention pertains.
BACKGROUND OF THE
Substituted indoles and uses thereof
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Throughout this application, various references are referred to within parentheses. Disclosures of these publications in their entireties are hereby incorporated by reference into this application to describe more fully the state of the art to which this invention pertains.
BACKGROUND OF THE
Substituted indoles and uses thereof
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BACKGROUND OF THE INVENTION
Alpha adrenergic receptors are plasma membrane receptors which are located in the peripheral and central nervous systems throughout the body. They are members of a diverse family of structurally related receptors which contain seven putative helical domains and transduce
Alleles of the human mu opioid receptor and diagnostic methods based thereon
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FIELD OF THE INVENTION
This invention relates generally to alleles of the human mu opioid receptor gene, along with products derived from such alleles. Also included herein are methods of diagnosing various susceptibilities using such alleles and determining treatment for certain diseases based upon
Alleles of the human mu opioid receptor, diagnostic methods using said alleles, and methods of treatment based thereon
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FIELD OF THE INVENTION
This invention relates generally to alleles of the human mu opioid receptor gene, along with products derived from such alleles. Also included herein are methods of diagnosing various susceptibilities using such alleles and determining treatment for certain diseases based upon
Benzamidine derivatives
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FIELD OF THE INVENTION
The present invention is directed to delta-opioid receptor modulators and methods for use thereof. More particularly, the present invention is directed to benzamidine derivatives which are delta-opioid receptor agonists or antagonists and methods for use thereof.
BACKGROUND OF
Substituted aminoquinuclidine compounds
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FIELD OF THE INVENTION
The present invention is directed to delta-opioid receptor modulators and methods for use thereof. More particularly, the present invention is directed to substituted aminoquinuclidine compounds which are delta-opioid receptor modulators, agonists or antagonists and methods
4-[aryl(piperidin-4-yl)]aminobenzamides
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The present invention relates to delta-opioid receptor agonists/antagonists. More particularly, the present invention relates to 4-[aryl(piperidin-4-yl)]aminobenzamides which are delta-opioid receptor agonists useful as analgesics.
BACKGROUND OF THE INVENTION
WO9723466 to Plobeck N. et al.,
3-(diheteroarylmethylene)-8-azabicyclo[3.2.1]octane and 3-((aryl)(heteroaryl)methylene)-8-azabicyclo[3.2.1]octane derivatives
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STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT
The research and development of the invention described below was not federally sponsored.
BACKGROUND OF THE INVENTION
WO 97/23466 describes compounds as having an analgesic effect of a general and one preferred formula:
##STR00001##
WO
3-(Diarylmethylene)-8-azabicyclo[3.2.1]octane derivatives
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FIELD OF THE INVENTION
The present invention is directed to compounds useful as delta-opioid and mu-opioid receptor modulators. More particularly, the present invention is directed to 3-(diarylmethylene)-8-azabicyclo[3.2.1]octane derivatives useful as delta-opioid or mu-opioid receptor
1,3-dialkylurea derivatives having a hydroxyl group
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This application is a 371 of PCT/JP95/02236 filed Nov. 1, 1995, published as WO96/14293 May 17, 1996.
TECHNICAL FIELD
The present invention relates to novel 1,3-dialkylurea derivatives having a hydroxyl group which have inhibitory effects on endopeptidase 24.11 and are useful as therapeutic agents
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