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13 hasil
Analgesic formulations and methods for reduced postoperative nausea and vomiting and enhanced postoperative pain relief
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FIELD OF THE INVENTION
The present invention relates to an analgesic formulation for pain control not limited to postoperative pain control.
BACKGROUND OF THE INVENTION
The treatment and relief of pain is one of the most common reasons patients seek medical evaluation. Pain has been defined by the
Quaternary derivatives of noroxymorphone which relieve nausea and emesis
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BACKGROUND OF THE INVENTION
The administration of therapeutic doses of morphine and other clinically useful narcotic analgesics is often accompanied by unpleasant side effects on the gastro-intestinal system. For instance, morphine and related opiates such as meperidine and methadone may retard
Quaternary derivatives of noroxymorphone which relieve nausea and emesis
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BACKGROUND
The administration of therapeutic doses of morphine and other clinically useful narcotic analgesics is often accompanied by unpleasant side effects on the gastro-intestinal system. For instance, morphine and related opiates such as meperidine and methadone may retard intestinal mobility
Compositions and methods for enhancing analgesic potency of tramadol and attenuating its adverse side effects
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BACKGROUND OF THE INVENTION
Morphine or other bimodally-acting opioid agonists are administered to relieve severe pain due to the fact that they have analgesic effects mediated by their activation of inhibitory opioid receptors on nociceptive neurons (see North, Trends Neurosci., Vol. 9, pp. 114-117
Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds
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This invention relates generally to methods for reducing, treating, reversing or preventing drug-mediated respiratory depression, such as may be directly or indirectly caused by use of various bioactive compositions, including anaesthetics, barbiturates, analgesics, etc. The invention further
Tetrazolyl-substituted quinuclidines as substance P antagonists
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TECHNICAL FIELD
This invention relates to novel tetrazolyl-substituted quinuclidine compounds and their pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and the use of such compounds as substance P antagonists.
BACKGROUND ART
Substance P is a naturally
Chemical compounds
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BACKGROUND OF THE INVENTION
The present invention relates to piperidine derivatives, to processes for their preparation, to pharmaceutical compositions containing them and to their medical use.
In particular the invention relates to novel compounds which are potent and specific antagonists of
Pharmaceutical preparations for the treatment of itch, nausea, hyperalgesia and the complications of opioid agonists
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention is relevant to the field of suppressing sensory afferent neuron mediated symptoms and the manufacture of agents and compositions which suppress the same.
2. Discussion of the Related Art.
Sensory afferent nerves mediate a
Biaryl benzoimidazole derivatives and pharmaceutical composition comprising the same
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TECHNICAL FIELD
The present invention relates to a novel biaryl benzoimidazole derivative, a method for preparing the same, and a pharmaceutical composition comprising the same, in which the biaryl benzoimidazole derivative functions as an antagonist of the vanilloid receptor (Capsaicin receptor;
Derivatives of substituted imidazol-2-one and process for their preparation
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The present invention relates to new derivatives of 1-phenyl-3-azabicycloalkyl-imidazolidin-2-ones, to a process for their preparation, to pharmaceutical compositions containing them and to their use as therapeutic agents.
The present invention provides novel compounds having the general formula (I)
Derivatives of substituted imidazol-2-one and process for their preparation
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The present invention relates to new derivatives of 1-phenyl-3-azabicycloalkyl-imidazolidin-2-ones, to a process for their preparation, to pharmaceutical compositions containing them and to their use as therapeutic agents.
The present invention provides novel compounds having the general formula (I)
Derivatives of substituted imidazo benzoxazin-1-one and process for their preparation
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The present invention relates to new derivatives of 2,3,3a,4-Tetrahydro-2-azabicycloalkyl-1H-imidazo [5,1-c][1,4]benzoxazin-1-one, to a process for their preparation, to pharmaceutical compositions containing them and to their use as therapeutic agents.
The present invention provides novel compounds
Cannabinoid receptor agonists
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BACKGROUND OF THE INVENTION
This invention relates to certain novel octahydro-3-alkoxy-9-alkyl-phenanthridines and derivatives thereof and pharmaceutically acceptable acid addition salts thereof useful as antiinflammatory, analgesics, immunosuppressive, antiemetic and intraocular pressure reducing
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