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anorexia/scopolamine

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Craniotomy-associated chronic emesis can be refractory to currently approved antiemetic therapy. The authors describe a man who suffered 4 weeks of severe refractory emesis, failure to thrive, and a 40-lb weight loss after he underwent resection of a posterior fossa cholesteatoma. The patient

Recurrent classic migraine attacks following transdermal scopolamine intoxication.

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A 20 year old male naval crew-member suffering from sea sickness was treated with transdermal scopolamine (TS). After 5 months of continuous treatment, he developed scopolamine intoxication followed by the appearance of recurrent classic migraine attacks. He had never suffered from headache or

Apomorphine anorexia: a further pharmacological characterization.

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Low doses of apomorphine reduce food intake, primarily by decreasing the rate of eating and also by reducing eating time. We have previously reported that the effect on eating time is mediated by dopamine cell body autoreceptors in the ventral tegmental area. The present experiments were designed to

Despite various drugs, cats continue to kill mice.

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Amphetamines (d- at 0.5--4 mg/kg; 1- at 2--4 mg/kg) inhibited spontaneous mouse killing by some, but not all cats. Various other drugs (drugs and maximum tested doses were: imipramine, 64 mg/kg; amitriptyline, 32 mg/kg; tranylcypromine, 2 mg/kg; tripelennamine, 4 mg/kg; scopolamine, 1 mg/kg; methyl

What the ancient Greeks and Romans knew (and did not know) about seasickness.

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OBJECTIVE To find and analyze descriptions in ancient Greek and Roman literature that reveal what was known at the time about seasickness. METHODS A systematic search was made in the original literature beginning in the Greek period with Homer in ca 800 bc and extending up to Aetios Amidenos in the

Treatment efficacy of intramuscular promethazine for space motion sickness.

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Intramuscular promethazine and its efficacy in the treatment of Space Motion Sickness (SMS) were evaluated using standardized questions administered during postflight debriefings to crewmembers immediately after their first Shuttle flight. Space Motion Sickness was graded as none, mild, moderate, or
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