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anthracene/sarkoma
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[The detection of the chicken sarcoma virus D6 in a tumor induced by 7,12-dimethylbenz(a)anthracene].
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A tumor induced by 7.12-dimethylbenz (a) anthracene in the hen is described from which a virus was isolated and classified as C type of Rous sarcoma virus. The virus is described in brief. It does not belong to any known strain of Rous sarcoma virus.
[Cytotoxic factors of neutrophils in rats with 7,12-dimethylbenz[a]anthracene-induced sarcoma].
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A study of intraleukocyte cytotoxic system and phagocytic function of granulocytes was carried out in rats with 7,12-dimethylbenz(a)anthracene-induced sarcoma. There were no distinctive alterations of microbicidal factors of polymorphonuclear neutrophils (PMN) at the initial stage of the tumour
[Cationic protein content in the leukocytes of rats with Pliss' lymphosarcoma and 7,12-dimethylbenz(a)anthracene-induced sarcoma].
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The level of intraleukocytic cationic proteins is studied in rats with the transplanted Pliss lymphosarcoma and sarcoma induced by 7,12-dimethylbenz(a)anthracene (DMBA). The amount of cationic proteins was found to decrease in granulocytes both of mongrel and Wistar rats with transplantable tumours.
Ras gene mutations in 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat sarcomas.
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Tumor induction in rats by 7,12-dimethylbenz[a]anthracene (DMBA) will generate malignancies that display reproducible chromosomal abnormalities involving rat chromosome (RNO) 2. Thus, it has been reported that rat DMBA erythroleukemias display RNO2 abnormalities, which in this case were closely
Induction of sarcomas by a single subcutaneous injection of 7,12-dimethylbenz[a]anthracene into neonatal male Sprague-Dawley rats: histopathological and immunohistochemical analyses.
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Animal experiments have shown that carcinogenicity of chemicals is higher in fetal or neonatal periods than adult. We investigated sensitivities to a carcinogen in peri-neonatal rats with a model of sarcomas-induction by a subcutaneous injection of chemo-carcinogen that has rarely done in neonatal
[Polyamine content in tissues of 7,12-dimethyl-benz(a)anthracene-induced sarcoma and liver of tumor-carrying rats].
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Putrescine in determinable amounts is contained in the tumour tissue, in the liver tissue of normal animals it was not detected by the applied method. The spermidine content in the tumour is also considerably higher, it is 15.-3 times as high as that in the normal liver both per 1 g of fresh tissue
The chromosomes of primary 7,12-dimethylbenz(a)anthracene-induced rat sarcomas.
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Lysosomal enzymes in rat sarcomas induced by 7,12-dimethylbenz(alpha)anthracene and Rous sarcoma virus.
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Chromosomes of six primary sarcomas induced in the Chinese hamster by 7,12-dimethylbenz(a)anthracene.
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Changes in the deoxyadenylate regions of rat DNA in sarcomas induced by 7,12-dimethylbenz(alpha)anthracene and Rous sarcoma virus.
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Comparative carcinogenicity of alkylating agents: comparisons of a series of alkyl and aralkyl bromides of differing chemical reactivities as inducers of sarcoma at the site of a single injection in the rat.
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A series of alkylating and aralkylating bromides was used in a comparative study of chemical reactivity (using 4-(p-nitrobenzyl) pyridine as standard nucleophile), and carcinogenic activity (using single injections by the subcutaneous route in 6-week old female CB-hooded rats). Benzyl, ethyl,
Two-stage carcinogenesis in NMRI mice: intravaginal application of 7,12-dimethylbenz[a]anthracene as initiator followed by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate as promoter.
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In this study a new modification of the systemic 2-stage carcinogenesis experiment is described. Tumors were induced in NMRI-mice using a single intravaginal application of the carcinogen 7,12-dimethylbenz[a]anthracene (DMBA) (initiator) followed by intravaginal treatment with
[Effects of neonatal androgenization on 7,12-dimethylbenz[a] anthracene-induced rat endometrial carcinogenesis].
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Effects of neonatal androgenization on 7,12-dimethylbenz[a]anthracene (DMBA)-induced endometrial carcinogenesis in Sprague-Dawley rats are studied. Testosterone propionate (1.25 mg) was injected subcutaneously into 110 2-day-old rats. At 8 weeks of age, a pellet containing 0.2 or 1mg DMBA was
In vitro malignant transformation of mouse fibroblasts by non-K-region dihydrodiols derived from 7-methylbenz(a)anthracene, 7,12-dimethylbenz(a)anthracene, and benzo(a)pyrene.
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The 8,9-dihydrodiols of 7-methylbenz(a)anthracene and 7,12-dimethylbenz(a)anthracene and the 7,8-dihydrodiol of benzo(a)pyrene, which are non-K-region diols with adjacent olefinic double bonds that can be metabolized to diol-epoxides, were more active than the parent hydrocarbons in inducing
Chemical transformation of human revertant cells induced by murine sarcoma virus.
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A human revertant cell line, derived from non-producer human osteosarcoma cells (NP/KHOS) induced by Kirsten murine sarcoma virus, was treated in vitro with various levels of polycyclic aromatic hydrocarbons (3-methylcholanthrene, 7,12-dimethylbenz(alpha)anthracene, and benzo(alpha)pyrene [BP] or
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