The present invention relates to N-acyl derivatives of amino acids and pharmaceutically acceptable salts thereof ##STR00001## wherein n is 2 or 3; and R.sub.1 represents ##STR00002## or pharmaceutically acceptable salts thereof, to novel processes for preparing the same, to use thereof as anti-allergic, anti-anaphylactic, anti-inflammatory and hypolipidemic agents as well as to a pharmaceutical composition comprising the indicated compounds in an efficient amount and to a method for treating allergic and inflammatory diseases and lipid metabolism disorders: bronchial asthma, allergic rhinitis, pollinoses, seasonal and year-round rhinitis, allergic pneumonitis, atopic dermatitis, psoriasis, urticaria, allergic (including anaphylactic) reactions to insect stings and medicaments, cold allergy, allergic conjunctivitis, atherosclerosis, obesity, ischemic heart and cerebral disease, myocardial infarction and stroke.

Otkrytoe Aktsionernoe Obschestvo-Otechestvennye Lekarstva

N-acyl amino acid derivatives, a method for the preparation thereof, a pharmaceutical composition and use thereof as anti-allergic, anti-inflammatory and hypolipidemic agents

Nebolsin; Vladimir Evgenievich

Kromova; Tatyana Alexandrovna

Zheltukhina; Galina Alexandrovna

Kovaleva; Violetta Leonidovna

Otkrytoe Aktsionernoe Obschestvo Otechestvennye Lekarstva

Vladimir Evgenievich Nebolsin

N-acylic aminoacid derivatives, method for the production thereof, pharmacological composition and the use in the form anti-allergic, anti-inflammatory and hypolipidemic agents

This invention relates to chemical compounds which possess valuable therapeutic activity particularly as lipoxygenase and phospholipase C inhibitors and as platelet-activating factor receptor antagonists. The compounds posses anti-inflammatory anti-asthmatic and anti-allergic properties and are additionally useful for the treatment of myocardial infarctions. The compounds of this invention are imidazolino-containing compounds of the general formula: ##STR1##

anti allergic/infark

N-acyl amino acid derivatives, a method for the preparation thereof, a pharmaceutical composition and use thereof as anti-allergic, anti-inflammatory and hypolipidemic agents

N-acylic aminoacid derivatives, method for the production thereof, pharmacological composition and the use in the form anti-allergic, anti-inflammatory and hypolipidemic agents

Bis-imidazolinoamino derivatives as antiallergy compounds

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