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anti inflammatory/diare
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5-ASA derivatives having anti-inflammatory and antibiotic activity and methods of treating diseases therewith
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FIELD OF THE INVENTION
The present invention relates to 5-ASA derivatives and methods of treating diseases therewith.
BACKGROUND OF THE INVENTION
Many people suffer from inflammatory bowel disease (IBD). TRD is a generic term used to refer to two inflammatory diseases, ulcerative colitis and Crohn's
4-[aryl(8-azabicyclo[3.2.1]octan-3-yl)]aminobenzoic acid derivatives
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FIELD OF THE INVENTION
The present invention is directed to delta-opioid receptor modulators. More particularly, the present invention is directed to 4-[aryl(8-azabicyclo[3.2.1]octan-3-yl)]aminobenzoic acid derivatives which are delta-opioid receptor modulators useful as effective
Heterocycle-fused morphinans, use thereof and preparation thereof
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TECHNICAL FIELD
The present disclosure relates to certain heterocycle fused morphianans. Compounds of the present disclosure are mixed mu agonist delta antagonists or dual mu agonist/delta agonists or antagonists at mu, delta and kappa opioid receptors. Compounds of the present disclosure are useful
Indenyl hydroxamic acids and hydroxy ureas as inhibitors of 5-lipoxygenase
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BACKGROUND OF THE INVENTION
The leukotrienes and their biological activities, especially their role in various disease states, have been extensively studied. Their properties are described in the book Leukotrienes and Lipoxygenases, Ed., J. Rokach, Elsevier, N.Y., 1989.
Inhibitors of the
Dibenzoheterocyclic hydroxamic acids and hydroxy ureas as inhibitors of 5-lipoxygenase
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BACKGROUND OF THE INVENTION
The leukotrienes and their biological activities, especially their role in various disease states, have been extensively studied. Their properties are described in the book Leukotrienes and Lipoxygenase, Ed., J. Rokach, Elsevier, N.Y., 1989.
Inhibitors of the
Plant polyphenols extraction and activation thereof
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The present invention relates to a method and process in the preparation of hydrogenated polyphenol particles. Particularly it relates to a process for preparing Polyphenols and second plant metabolites particles by a dispersing agent.
BACKGROUND
The uses of herbal medicines are known in cultures
(Quinolin-2-ylmethoxy)indole/cyclodextrin complex
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BACKGROUND OF THE INVENTION
EP 419,049, Prasit et al., Mar. 27, 1991, describes a series of quinolin-2-ylmethoxy indoles useful as inhibitors of leukotriene biosynthesis. Examples 1 and 1A therein teach the synthesis of 3-[N-(p-chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-ylmethoxy)indol-2-yl]-
(Azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis
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BACKGROUND OF THE INVENTION
European Patent Applications 166,591 and 275,667 disclose a series of indole-based compounds with activity as prostaglandin antagonists and inhibitors of leukotriene biosynthesis respectively. In EP 181,568 and EP 200,101 are disclosed a series of compounds, containing
(hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis
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BACKGROUND OF THE INVENTION
European Patent Applications 166,591 and 275,667 disclose a series of indole-based compounds with activity as prostaglandin antagonists and inhibitors of leukotriene biosynthesis respectively. In EP 181,568 and EP 200,101 are disclosed a series of compounds, containing
Bicyclic-azaarylmethoxy) indoles as inhibitors of leukotriene biosynthesis
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BACKGROUND OF THE INVENTION
European Patent Applications 166,591 and 275,667 disclose a series of indole-based compounds with activity as prostaglandin antagonists and inhibitors of leukotriene biosynthesis respectively. In EP 181,568 and EP 200,101 are disclosed a series of compounds, containing
(Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis
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BACKGROUND OF THE INVENTION
European Patent Applications 166,591 and 275,667 disclose a series of indole-based compounds with activity as prostaglandin antagonists and inhibitors of leukotriene biosynthesis respectively. In EP 181,568 and EP 200,101 are disclosed a series of compounds, containing
Fluorinated quinoline indoles as inhibitors of the biosynthesis of leukotrienes
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CROSS REFERENCE
The compounds of Formula I' are described in U.S. Ser. No. 650,825 filed Feb. 5, 1991, which is now U.S. Pat. No. 5,204,344, and incorporated herein by reference.
BACKGROUND OF THE INVENTION
European Patent Applications 166,591 and 275,667 disclose a series of indole-based compounds
Amorphous (quinolin-2-ylmethoxy)indole compounds which have useful pharmaceutical utility
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BACKGROUND OF THE INVENTION
EP 419,049, Prasit et al., Mar. 27, 1991, describes a series of quinolin-2-ylmethoxy indoles useful as inhibitors of leukotriene biosynthesis. Examples 1 and 1A therein teach the synthesis of 3-[N-(p-chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-ylmethoxy)indol-2-yl]-
Amorphous (quinolin-2-ylmethoxy)indole compounds useful for treating inflammatory diseases
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BACKGROUND OF THE INVENTION
EP 419,049, Prasit et al., Mar. 27, 1991, describes a series of quinolin-2-ylmethoxy indoles useful as inhibitors of leukotriene biosynthesis. Examples 1 and 1A therein teach the synthesis of 3-[N-(p-chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-ylmethoxy)indol-2-yl]-
(Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes
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BACKGROUND OF THE INVENTION
European Patent Applications 166,591 and 275,667 disclose a series of indole-based compounds with activity as prostaglandin antagonists and inhibitors of leukotriene biosynthesis respectively. In EP 181,568 and EP 200,101 are disclosed a series of compounds, containing
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