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anticonvulsants/hypoxia
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Effects of non-opioid antitussives on hypoxia-induced electrical changes in rat hippocampal slices: a comparative study with anticonvulsant drugs.
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1. The effects of the non-opioid antitussives caramiphen and carbetapentane and of the anticonvulsants 5,5-diphenylhydantoin and MK 801 were tested towards hypoxia-induced electrical changes in rat hippocampal slices. 2. The incidence of appearance of hypoxia-induced epileptiform bursting was
The synthesis of prostaglandins and thromboxane in the mouse brain in vivo. Influence of drug induced convulsions, hypoxia and the anticonvulsants trimethadione and diazepam.
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1. The i.v. administration of convulsant doses of penetrazole or picrotoxin induced an increase in PGF2 alpha, PGE2 and TXB2-like immunoreactive material in mouse brain tissue. The onset of increase coincided with the appearance of clonic seizures. 2. The anticonvulsant drugs trimethadione and
[Anticonvulsant effects of carbon dioxide and hypoxia].
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Do anticonvulsant drugs exert protective effect against hypoxia?
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Sex differences in the anticonvulsant activity of neurosteroids.
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Epilepsy is one of the leading causes of chronic neurological morbidity worldwide. Acquired epilepsy may result from a number of conditions, such as brain injury, anoxia, tumors, stroke, neurotoxicity, and prolonged seizures. Sex differences have been observed in many seizure types; however, some
Nicotine reduces mortality of developing rats exposed to high-altitude hypoxia and partially suppresses the duration of cortical epileptic afterdischarges.
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Nicotine has been repeatedly reported as substance possessing neuroprotective properties. This study focused on the possible beneficial effects of nicotine against the high-altitude hypoxia (9000 m for one hour). 15 min prior to hypoxia exposition rats (12- and 35-day-old) were treated with
Protection against hypoxia-induced lethality in mice: a comparison of the effects of hypothermia and drugs.
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The role of hypothermia in the antihypoxic effects of drugs was examined in the present experiments. The effects of environmentally induced hypothermia and drugs were tested by exposing mice to 100% nitrogen gas for 80 sec and counting the number of survivors. In a series of 68 vehicle control
Truncal ataxia in chronic anticonvulsant treatment. Association with drug-induced folate deficiency.
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The association of truncal ataxia with a number of different factors has been studied in a group of 95 epileptic outpatients on chronic anticonvulsant treatment. The 28 patients showing truncal ataxia had been epileptic for a longer period of time, received a significantly larger number of drugs,
Time-dependent rundown of GABA response in mammalian cns neuron during experimental anoxia.
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Gamma-Aminobirtyric acid (GABA) is one of the major neurotransmitters in the mammalian central nervous system (CNS). The activation of post-synaptic GABAA receptor-chloride channel complex is thought to underlie inhibitory postsynaptic potentials ubiquitously in various CNS regions. GABAA receptors
Effects of phenobarbital on cerebral blood flow during hypoxia.
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Phenobarbital (PB), at anticonvulsant dosages, has been used in an attempt to reduce hypoxic brain injury in asphyxiated newborn infants. The effects of PB pretreatment on the cerebral blood flow (CBF) response in hypoxia were studied in 15 curarized and mechanically ventilated piglets: 7 animals
Protective effects of felbamate against hypoxia in the rat hippocampal slice.
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OBJECTIVE
Felbamate is a new dicarbamate anticonvulsant with low toxicity currently being investigated in human clinical epilepsy trials. In this study, we examined the protective effects of felbamate against hypoxia.
METHODS
We exposed paired rat hippocampal slices to hypoxia with and without
Brain vasoactive effects of phenobarbital during hypertension and hypoxia in newborn pigs.
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Phenobarbital in anticonvulsant concentrations has been shown to lower cerebral blood flow (CBF) during hypertension and to reduce the incidence of intraventricular hemorrhage in newborn beagles after hypertensive insult. We proposed that hypoxic dilatation of brain blood vessels might alter the
[Effects of acute hypoxia on the development of corazol-induced seizures].
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Experiments on white random-bred rats showed that development of corazol seizures depend both on corazol dose and pO2 level in atmosphere. Latent period becomes short, the time of convulsive attack and the time of all seizures prolongs with increase of corazol dose. Acute hypoxia inhibits
Inhibitory effects of NMDA receptor antagonists on hypoxia-induced seizures in dietary Mg(2+)-deficient mice.
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The effects of the non-competitive N-methyl-D-aspartate (NMDA) antagonists, (+)-MK-801 hydrogen maleate (MK-801) and phencyclidine hydrochloride (PCP), were tested against hypoxia-induced tonic convulsions and hippocampal epileptiform discharges. Systemic administration of MK-801 and PCP suppressed
Chronic Oxytocin treatment has long lasting therapeutic potential in a rat model of neonatal hypercapnic-hypoxia injury, through enhanced GABAergic signaling and by reducing hippocampal gliosis with its anti-inflammatory feature
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Previous studies have shown that, oxytocin has anticonvulsant and neuroprotective effects. One of the most important complications of Hypercapnic-hypoxia is drug resistance epilepsy. Effects of chronic intraperitoneal oxytocin treatment on gliosis, neuroinflammation and seizure activity was
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