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antifungal/hypoxia
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Tissue specific hypoxia regulated therapeutic constructs
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FIELD OF THE INVENTION
This invention relates to chimeric genes (e.g., carried on expression vectors) containing therapeutic genes whose expression is under the control of tissue specific and hypoxia response enhancer elements.
REFERENCES
Ascadi, G., et al., Nature 352:815 (1991b).
Ascadi, G., et
Hypoxia-responsive nanoparticle for therapy and imaging of hypoxia-involving diseases
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TECHNICAL FIELD
The present invention relates to nanoparticles that change their properties under hypoxic conditions, and thus can be used for the diagnosis and treatment of hypoxia-related diseases.
BACKGROUND ART
Hypoxia, a pathological condition deprived of adequate oxygen supply, is a hallmark
Identification of compounds that modify transcriptional responses to hypoxia
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BACKGROUND OF THE INVENTION
This invention relates to methods for identifying compounds that modify transcriptional responses to hypoxia.
As solid tumors evolve from a single malignant cell into a multicellular mass, oxygen tension in the tumor microenvironment drops as the passive diffusional
FROG/TOAD conditionally silenced vectors for hypoxia gene therapy
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FIELD OF THE INVENTION
Embodiments of the invention comprise methods of treating hypoxia and associated conditions. In particular, directional therapeutic angiogenesis induced in patients via a conditionally silenced vector expressing a desired factor.
BACKGROUND
Therapeutic angiogenesis is a
cDNAs and proteins involved in hypoxia, circadian and orphan signal transduction pathways, and methods of use
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FIELD OF THE INVENTION
This invention relates to the field of molecular signaling and physiological responses to external stimuli. In particular, this invention provides nucleic acid molecules and proteins that constitute new members of the bHLH-PAS superfamily of transcription
cDNAs and proteins involved in hypoxia, circadian and orphan signal transduction pathways, and methods of use
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FIELD OF THE INVENTION
This invention relates to the field of molecular signaling and physiological responses to external stimuli. In particular, this invention provides nucleic acid molecules and proteins that constitute new members of the bHLH-PAS superfamily of transcription
Stimulation of therapeutic angiogenesis by T regulatory cells
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FIELD
The invention pertains to the field of immunology, more specifically, the invention pertains to the use of T regulatory cells, classically known as immunological cells, to stimulate angiogenesis. The invention pertains to utilization of cells to stimulate angiogenesis, more particularly, the
Method of extending the vascular dwell-time of particulate therapeutic and particulate diagnostic agents
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TABLE OF CONTENTS
1. Technical Field
2. Background of the Invention
3. Summary of the Invention
4. Detailed Description of the Invention
4.1 The Mode of the Invention
4.2 Mode of Administration
5. Examples
5.1 Biological Data
1. TECHNICAL FIELD
The present invention relates to a method for
Method of extending the vascular dwell-time of particulate therapeutic and particulate diagnostic agents
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1. TECHNICAL FIELD
The present invention relates to a method for increasing the vascular dwell-time of a particulate therapeutic or particulate diagnostic agent in a mammal through the adjunct administration of an effective amount of the particulate therapeutic or particulate diagnostic agent and an
Composition and method for detecting hypoxia
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TECHNICAL FIELD
The presently-disclosed subject matter relates to compounds for detecting hypoxia and methods thereof. More particularly, the presently-disclosed subject matter relates to hypoxia targeted fluorescence imaging agents and methods in detection and treatment of retinal
Therapeutic uses of oligomers of 15-dehydroprostaglandin B.sub.1 and oligomers of derivatives of 15-dehydroprostaglandin B1
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BACKGROUND OF THE INVENTION
This invention relates to the therapeutic uses of oligomers of 15-dehydroprostaglandin B.sub.1 and oligomers of 16, 16'-dimethyl-15-dehydro PGB.sub.1 and oligomers of other 16 carbon substituted 15-dehydro PGB.sub.1 compounds (hereinafter referred to as oligomers of
Compositions comprising hypoxia inducible factor-1 alpha and methods of using the same
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TECHNICAL FIELD
The present invention relates to compositions comprising hypoxia inducible factor-1 alpha (HIF-1.alpha.) and methods of treating hypoxia or ischemia.
BACKGROUND
In mammals, embryo development and maintenance of adult homeostatsis depend on the establishment of a functional vascular
Tissue specific hypoxia regulated constructs
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FIELD OF THE INVENTION
This invention relates to chimeric genes (e.g., carried on expression vectors) containing therapeutic genes whose expression is under the control of tissue specific and hypoxia response enhancer elements.
REFERENCES
Ascadi, G., et al., New Biology 3:71 (1991a).
Ascadi, G., et
Therapeutic composition
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BACKGROUND OF THE INVENTION
The present invention relates to the prophylactic and therapeutic treatment of hypoxia and ischemic tissue disease. Phosphonate compounds are administered therapeutically to protect a tissue or organ against degeneration, necrosis and fibrosis following blockage of the
Therapeutic composition
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BACKGROUND OF THE INVENTION
The present invention relates to the prophylactic and therapeutic treatment of hypoxia and ischemic tissue disease. Phosphonate compounds are administered therapeutically to protect a tissue or organ against degeneration, necrosis and fibrosis following blockage of the
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