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Aptamers to tissue factor pathway inhibitor and their use as bleeding disorder therapeutics
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INCORPORATION-BY-REFERENCE OF SEQUENCE LISTING
The contents of the text file named "ARC612USsubseqlist.txt," which was created on Jan. 3, 2011 and is 149 KB in size, are hereby incorporated by reference in their entirety.
FIELD OF THE INVENTION
The invention relates generally to the field of nucleic
Aptamers to tissue factor pathway inhibitor and their use as bleeding disorder therapeutics
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FIELD OF THE INVENTION
The invention relates generally to the field of nucleic acids and more particularly to aptamers that bind to tissue factor pathway inhibitor (TFPI), which are useful as therapeutics in and diagnostics of bleeding disorders and/or other pathologies, diseases or disorders in
Small molecule therapeutic compounds that reduce the incidence of intracerebral hemorrhage and brain microhemorrhages
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FIELD OF THE INVENTION
The described invention relates to small molecule therapeutic compounds capable of reducing the incidence of intracerebral hemorrhage and brain microhemorrhages.
BACKGROUND
Many pathologic conditions cause a destabilization of the vascular network resulting in endothelial
Antithrombotic and non-hemorrhagic heparin-based compositions, process for their preparation and therapeutic applications
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The present invention relates to heparin-based compositions as well as to a process for their preparation and to their therapeutic applications.
The invention relates more particularly to heparin-based compositions neutralized with protamine, having antithrombotic activity but largely devoid of
Therapeutic uses of BPI protein products in humans with hemorrhage due to trauma
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BACKGROUND OF THE INVENTION
The present invention relates generally to methods and materials for treating humans suffering from hemorrhage due to trauma, by administration of bactericidal/permeability-increasing (BPI) protein products.
Acute traumatic hemorrhage, generally requiring immediate
Therapeutic agent for the prevention of intraventricular hemorrhage in premature infants
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DETAILED DESCRIPTION OF THE INVENTION
1. Field of the Invention
The present invention relates to a therapeutic agent for the prevention of intraventricular hemorrhage in premature infants.
2. Prior Art
Intraventricular hemorrhage of newborn infants is one of the diseases resulting in a very high
Surgical method and apparatus for positioning a diagnostic or therapeutic element within the body and forming an incision in tissue with minimal blood loss
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BACKGROUND OF THE INVENTIONS
1. Field of Invention
The present inventions relate generally to structures for positioning one or more diagnostic or therapeutic elements within the body and, more particularly, to devices which are particularly well suited for treatment of cardiac conditions.
2.
Substance abuse-induced hemorrhagic stoke in an animal model
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BACKGROUND OF THE INVENTION
Despite its reputation as a beverage that can be used socially, acute "binge-drinking" of alcohol (e.g., more than 80 g ingested in <24 h) is associated with an ever-growing number of strokes and sudden death. This type of "binge-drinking" has been shown to result in
Therapeutical method for treating infection of mink hemorrhagic pneumonitis
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BACKGROUND OF THE INVENTION
Pseudomonas aeruginosa is known to be naturally resistant against most of antibiotics commonly used. Although there are only a few antibiotics to which the bacteria are sensitive, the use of these antibiotics in the therapy of infections due to Pseudomonas aeruginosa is
Use of oral interleukin-6 as therapy for hemorrhagic shock
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FIELD OF THE INVENTION
This invention relates generally to bio-affecting and body treating drug compositions, and more particularly to amelioration of the adverse effects of hemorrhagic shock by administration of lymphokines.
BACKGROUND OF THE INVENTION
Severe trauma frequently results in massive
Aptamers to tissue factor pathway inhibitor and their use as bleeding disorder thereapeutics
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FIELD OF THE INVENTION
The invention relates generally to the field of nucleic acids and more particularly to aptamers that bind to tissue factor pathway inhibitor (TFPI), which are useful as therapeutics in and diagnostics of bleeding disorders and/or other pathologies, diseases or disorders in
Factor IX variants with clotting activity in absence of their cofactor and/or with increased F.IX clotting activity and their use for treating bleeding disorders
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CROSS REFERENCE TO A RELATED APPLICATION
This application is a National Stage Application of International Application Number PCT/EP2014/076435, filed Dec. 3, 2014; which claims priority to European Application No. 13196284.7, filed Dec. 9, 2013.
The Sequence Listing for this application is labeled
Factor IX variants with clotting activity in absence of their cofactor and/or with increased F.IX clotting activity and their use for treating bleeding disorders
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The Sequence Listing for this application is labeled "SeqList-08Jun16.txt", which was created on Jun. 8, 2016, and is 7 KB. The entire content is incorporated herein by reference in its entirety.
FIELD OF THE INVENTION
The present invention relates to variants of factor IX (F.IX) or activated factor
Treatment of hemorrhagic shock
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BACKGROUND OF THE INVENTION
The present invention relates to the process of treating warm blooded animals including humans who are in an anoxemic state. Specifically it relates to the treatment of lactic acidosis in warm blooded animals and certain conditions of the body believed to be caused by
Fibrinogen bandages and arterial bleeding models and methods of making and using thereof
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates generally to fibrinogen bandages and arterial bleeding models and methods of making and using thereof. In particular, the present invention relates to a fibrinogen bandage having propyl gallate and a swine arterial bleeding
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