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antirheumatics/pendarahan
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Anti-rheumatic and analgesic drug usage and acute gastro-intestinal bleeding in elderly patients.
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The records of 1878 general medical in-patients (aged 75 years and over) at Hereford have been examined for associations between the commonly used antirheumatic and analgesic drugs and acute gastro-intestinal bleeding. One third of 93 in-patients admitted because of acute bleeding had been taking
Nonsteroidal antiinflammatory drug-induced small intestinal inflammation and blood loss. Effects of sulfasalazine and other disease-modifying antirheumatic drugs.
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OBJECTIVE
To identify the source of intestinal blood loss in rheumatoid arthritis patients being treated with nonsteroidal antiinflammatory drugs (NSAIDs) and assess the response to sulfasalazine and other disease-modifying antirheumatic drugs (DMARDs).
METHODS
Intestinal inflammation, blood loss,
[Comparative experimental studies in animals and humans on gastrointestinal blood loss following antirheumatic pharmacotherapy (author's transl)].
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The gastrointestinal blood loss caused by the two antirheumatic drugs acetyl salicylic acid (ASA) and 4-acetamidophenyl-2-acetoxybenzoate (benorilate, Benortan) was compared in experimental animals and humans by measuring the total body iron retention. In Wistar rats and humans the results indicate
[Accumulation of risk factors before acute gastroduodenal hemorrhage: analgesic/antirheumatic drugs, alcohol and ulcer anamnesis].
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72 patients with acute hemorrhage from gastroduodenal peptic lesions were asked about their drug and alcohol consumption as well as about their smoking habits, 43 of them (60%) had used analgetic or antiinflammatory drugs on at least 3 days during the week preceding the gastrointestinal (g. i.)
[Antirheumatic drugs and bleeding in upper part of the gastrointestinal tract in terms of urgent endoscopic diagnosis (author's transl)].
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The role of analgesic antirheumatic drugs in precipitating acute upper gastrointestinal bleeding.
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[Stomach perforation and hemorrhage after long-term administration of antirheumatic agents].
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[Hemorrhagic complications of antirheumatic therapy].
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[Bleeding after endoscopic biopsy and polypectomy--do nonsteroidal anti-rheumatic drugs increase the risk?].
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[SSRI-associated bleeding risk].
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Secondary to their antidepressive effect, selective serotonin reuptake inhibitors (SSRI) also lead to a diminished platelet aggregation, which results in an increased risk of bleeding. This adverse effect is added to the therapeutic effects of antiplatelet drugs. Furthermore, combination with
Diffuse Alveolar Hemorrhage in a Patient with Antisynthetase Syndrome.
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An alveolar hemorrhage case is reported as the initial manifestation of antisynthetase syndrome in a 40-year-old man, who is admitted to the Emergency Department for diagnostic approach of chronic cough and progressive dyspnea. The diagnosis of the alveolar hemorrhage was based on the presence of
Endoscopic therapy and early elective operation as a therapeutic regimen in ulcer bleeding.
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In a prospective protocol we treated 63 consecutive patients admitted to our surgical department with bleeding gastroduodenal ulcers between January 1986 and December 1987. The therapeutic regimen included emergency endoscopy in all cases. Active Forrest Ia or II hemorrhage was treated
New antirheumatic agents: Fenoprofen calcium (Nalfon), naproxen (Naprosyn), and tolmetin sodium (Tolectin).
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The new antirheumatic agents, fenoprofen calcium, naproxen, and tolmetin sodium, are effective in the management of rheumatoid arthritis. Their efficacy is comparable, but not superior, to that of aspirin in usual oral doses. These agents also may be useful in degenerative joint disease and
Evaluation of ibuprofen (Motrin). A new antirheumatic agent.
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Ibuprofen is a new, mild analgesic agent that may be useful in the symptomatic treatment of rheumatoid arthritis and osteoarthritis. Results of clinical studies have shown that its beneficial effects in these conditions are comparable, but not superior, to those of aspirin. However, at recommended
[Abnormal menstrual bleeding].
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Abnormal uterine bleeding (DUB) is one of the most frequent gynecologic problems. Not every DUB is pathological, yet most women feel disordered. Recurrent DUB needs a diagnostic work-up and has to be treated frequently. 80% of cases are due to hormonal disorders, called dysfunctional uterine
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