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Halaman 1 dari 182 hasil
Method of treating emesis, anxiety and/or IBS
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The present invention relates to a method of treatment of emesis, such as cytotoxic agent or radiation induced nausea and vomiting or motion sickness; anxiety; and irritable bowel syndrome (IBS); in mammals including humans, and to the use of compounds in the preparation of a medicament for the
Treatment of emesis, nausea and vomiting
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The present invention relates to a method of treatment of emesis, such as cytotoxic agent or radiation induced nausea and vomiting or motion sickness; anxiety; and irritable bowel syndrome (IBS); in mammals including humans, and to the use of compounds in the preparation of a medicament for the
Methods for treating emesis and nausea using optically pure R(+) ondansetron
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BACKGROUND OF THE INVENTION
This invention relates to novel compositions of matter containing optically pure R(+) ondansetron. These novel compositions have potent antiemetic activity and are useful in ameliorating the nausea and vomiting otherwise induced by cancer chemotherapeutic agents and
Five-membered ring systems with bonded imidazolyl ring substituents
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This invention relates to a class of 5-membered heterocyclic compounds having at least one heteroatom, which are useful in the treatment of psychotic disorders (e.g. schizophrenia and mania); anxiety; alcohol or drug withdrawal or dependence; pain; gastric stasis; gastric dysfunction (such as occurs
Spirocyclic compounds incorporating five-membered rings with two heteroatoms for treating psychotic disorders, etc.
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This invention relates to a class of spirocyclic compounds which are useful in the treatment of psychotic disorders (e.g. schizophrenia and mania); anxiety; alcohol or drug withdrawal or dependence; pain; gastric stasis; gastric dysfunction (such as occurs with dyspepsia, peptic ulcer, reflux
Physiologically active 1,2,4,-oxa- and thiadiazoles
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This invention relates to a class of 5-membered heterocyclic compounds having at least one heteroatom, which are useful in the treatment of psychotic disorders (e.g. schizophrenia and mania); anxiety; alcohol or drug withdrawal; pain; gastric stasis; gastric dysfunction (such as occurs with
Substituted dihydro benzocycloalkyloxymethyl oxazolopyrimidinones, preparation and use thereof
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to a series of substituted dihydro benzocycloalkyloxymethyl oxazolopyrimidinones. More specifically, the present invention relates to a series of substituted
Substituted dihydro, trihydro and tetrahydro cycloalkyloxazolopyrimidinones, preparation and use thereof
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to a series of substituted dihydro, trihydro and tetrahydro cycloalkyloxazolopyrimidinones. More specifically, the present invention relates to a series of 2-substituted-di- tri or
Substituted dihydro and tetrahydro oxazolopyrimidinones, preparation and use thereof
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to a series of substituted dihydro and tetrahydro oxazolopyrimidinones. More specifically, the present invention relates to a series of 2-substituted-2,3-dihydro-oxazolo[3,2-a]pyrimidin-7-ones and
Azabicyclic amine derivatives and their use as therapeutic agents
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CROSS REFERENCE TO RELATED APPLICATIONS
This application claims priority under 35 U.S.C. .sctn.119 from GB Application No. 0108971.3, filed Apr. 10, 2001.
The present invention provides compounds of the formula (I): ##STR2##
wherein X represents hydrogen or a C.sub.1-4 alkyl group optionally
Tetrahydropyran derivatives and their use as therapeutic agents
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This invention relates to a class of tetrahydropyran compounds which are useful as tachykinin antagonists. More particularly, the compounds of the invention are useful as neurokinin 1 (NK-1) receptor antagonists.
By virtue of their excellent specificity for the human NK-1 receptor, the compounds of
Phenyl pyrrolidine ether tachykinin receptor antagonists
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BACKGROUND OF THE INVENTION
Substance P is a naturally occurring undecapeptide belonging to the tachykinin family of peptides, the latter being so-named because of their prompt contractile action on extravascular smooth muscle tissue. The tachykinins are distinguished by a conserved
Indole derivatives
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This invention relates to indole derivatives, to processes for their preparation, to pharmaceutical compositions containing them and to their medical use.
In particular the invention relates to compounds which are potent and selective antagonists of 5-hydroxytryptamine (5-HT) at 5-HT receptors of
Indole derivatives
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This invention relates to heterocyclic compounds, to processes for their preparation, to pharmaceutical compositions containing them and to their medical use. In particular the invention relates to compounds which act upon 5-hydroxytryptamine (5-HT) receptors of the type located on terminals of
Octahydropyrano[3,4-C]pyrrole tachykinin receptor antagonists
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BACKGROUND OF THE INVENTION
Substance P is a naturally occurring undecapeptide belonging to the tachykinin family of peptides, the latter being so-named because of their prompt contractile action on extravascular smooth muscle tissue. The tachykinins are distinguished by a conserved
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