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breast neoplasms/obesitas
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Small molecules for treating breast cancer
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BACKGROUND
Approximately 70% of newly diagnosed breast cancer patients are estrogen receptor-.alpha. positive (ER+). However, almost 50% of all ER+ breast tumors will not respond to endocrine therapy. Tamoxifen produces an overall 26% proportional reduction in mortality but many ER+ tumors that show
Compounds and methods for modulation of estrogen receptors
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TECHNICAL FIELD
This invention is generally directed to estrogen antagonists and agonists, including pharmaceutical compositions and uses thereof, and more specifically to compounds which selectively modulate estrogen receptor-beta (ER-.beta.) activity.
BACKGROUND OF THE INVENTION
The estrogen
Compounds and methods for modulation of estrogen receptors
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TECHNICAL FIELD
This invention is generally directed to estrogen antagonists and agonists, including pharmaceutical compositions and uses thereof, and more specifically to compounds which selectively modulate estrogen receptor-beta (ER-.beta.) activity.
BACKGROUND OF THE INVENTION
The estrogen
Compounds and methods for modulation of estrogen receptors
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TECHNICAL FIELD
This invention is generally directed to estrogen antagonists and agonists, including pharmaceutical compositions and uses thereof, and more specifically to compounds which selectively modulate estrogen receptor-beta (ER-.beta.) activity.
BACKGROUND OF THE INVENTION
The estrogen
Compounds and methods for modulation of estrogen receptors
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TECHNICAL FIELD
This invention is generally directed to estrogen antagonists and agonists, including pharmaceutical compositions and uses thereof, and more specifically to compounds which selectively modulate estrogen receptor-beta (ER-.beta.) activity.
BACKGROUND OF THE INVENTION
The estrogen
Compounds and methods for modulation of estrogen receptors
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TECHNICAL FIELD
This invention is generally directed to estrogen antagonists and agonists, including pharmaceutical compositions and uses thereof, and more specifically to compounds which selectively modulate estrogen receptor-beta (ER-.beta.) activity.
BACKGROUND OF THE INVENTION
The estrogen
Compounds and methods for modulation of estrogen receptors
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TECHNICAL FIELD
This invention is generally directed to estrogen antagonists and agonists, and to compounds for inhibiting cytokines, as well as to pharmaceutical compositions and methods related thereto.
BACKGROUND OF THE INVENTION
The estrogen hormone has a broad spectrum of effects on tissues in
Compounds and methods for modulation of estrogen receptors
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TECHNICAL FIELD
This invention is generally directed to estrogen antagonists and agonists, and to compounds for inhibiting cytokines, as well as to pharmaceutical compositions and methods related thereto.
BACKGROUND OF THE INVENTION
The estrogen hormone has a broad spectrum of effects on tissues in
Organic compounds
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The present invention relates to novel imidazole derivatives that are used as aldosterone synthase and aromatase inhibitors, as well as for treatment of a disorder or disease mediated by aldosterone synthase or aromatase.
The present invention provides a compound of formula (I)
##STR00002## wherein
Organic compounds
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The present invention relates to novel imidazole derivatives that are used as aldosterone synthase and aromatase inhibitors, as well as for treatment of a disorder or disease mediated by aldosterone synthase or aromatase.
The present invention provides a compound of formula (I)
##STR00002## wherein
Organic compounds
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The present invention relates to novel imidazole derivatives that are used as aldosterone synthase and aromatase inhibitors, as well as for treatment of a disorder or disease mediated by aldosterone synthase or aromatase.
The present invention provides a compound of formula (I)
##STR00002## wherein
Compounds and methods for modulation of estrogen receptors
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TECHNICAL FIELD
This invention is generally directed to estrogen antagonists and agonists, and to compounds for inhibiting cytokines, and more specifically to compounds which selectively modulate estrogen receptor-beta (ER-.beta.) activity, as well as to pharmaceutical compositions and methods
Substituted thiazolidinedione indazoles, indoles and benzotriazoles as estrogen-related receptor-.alpha. modulators
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FIELD OF THE INVENTION
The present invention relates to certain novel compounds, methods for preparing compounds, compositions, intermediates and derivatives thereof and for treating conditions such as cancer, arthritis, inflammatory airway disease, and metabolic disorders. More particularly, the
Human cachexia associated protein
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FIELD OF THE INVENTION
The present invention is in the field of molecular biology; more particularly, the present invention describes the nucleic acid and amino acid sequences of a human, cachexia-associated protein.
BACKGROUND OF THE INVENTION
The characteristic wasting anorexia associated with
LKB1-AMPK activators for therapeutic use in polycystic kidney disease
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BACKGROUND
Autosomal dominant polycystic kidney disease (ADPKD) is a frequently inherited kidney disorder with a gene frequency of 1 in 500 to 1,000 births affecting nearly 600,000 Americans and as many as 12 million people worldwide. This potentially lethal genetic disease is characterized by the
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