Women receiving adjuvant aromates-inhibitor with arhtralgia grade ≥ 1 (CTACAE 4.03)

Breast Cancer

Hormone Receptor Positive Tumor

Arthralgia

All patients were required to take an OPERA® capsule (dietary supplement where α-lipoic acid, Boswellia Serrata, methylsulfonylmethane and bromelain are combined in a single capsule) once daily,from enrollment up to sixth months.

OPERA

Azienda Ospedaliero Universitaria Careggi

Opera® for Aromatase Inhibitor-related Arthralgia Management (AIA)

Use of an Alfa-lipoic, Methylsulfonylmethane and Bromelain Dietary Supplement (Opera®) for Aromatase Inhibitor-related Arthralgia Management (AIA)

Reduction of AI-induced arthralgia assessed with VAS scale (0, no pain, to 5, worst pain)

Reduction of AI-induced arthralgia assessed with PRAI questionnaire (16 items that query pain severity over the last 7 days in eight joints using a rating scale of 0-10, with 10 being greatest severity)

Quality of life assessed with FACT-ES questionnaire (19 items which assess endocrine complaints and adverse effects with response scores ranging from 0 to 4 ('not at all', 'a little bit', 'somewhat', 'quite a bit', and 'very much.')

Compliance to AI therapy (percentage of patients that have not discontinued and/or changed originally prescribed anti-aromatase inhibitor)

bromelain/kanker payudara

Opera® for Aromatase Inhibitor-related Arthralgia Management (AIA)

Complementary Therapies for the Reduction of Side Effects During Chemotherapy for Breast Cancer

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