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In vivo anti-inflammatory activity of saponins from Bupleurum rotundifolium.
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Seven oleanane-type triterpene saponins were isolated from the methanolic extract of the aerial parts of Bupleurum rotundifolium. They were identified on the basis of their spectral data as 3-O-[alpha-L-rhamnopyranosyl (1-->2)-beta-D-glucopyranosyl
In vivo and in vitro antiinflammatory activity of saikosaponins.
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Buddlejasaponin I and saikosaponin 1 and 2, biologically active compounds from Scrophularia scorodonia and Bupleurum rigidum respectively, exert potent in vivo antiinflammatory effects on mouse ear edema induced by phorbol myristate acetate (PMA). The effects of these compounds on swelling and other
Anti-inflammatory activity of unusual lupane saponins from Bupleurum fruticescens.
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Extracts from Bupleurum fruticescens were examined for oral and topical anti-inflammatory activities. The BuOH extract proved to be active against carrageenan and tetradecanoylphorbol acetate acute edemas and allowed the isolation of three saponins identified by spectroscopic techniques as 3
Comparative study of different essential oils of Bupleurum gibraltaricum Lamarck.
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A comparative study was performed of the essential oil extracted from the fruiting apex of Bupleurum gibraltaricum Lamarck (Umbelliferae) collected in different areas within the province of Granada, including the Cázulas mountains, the Balcón de Canales and the Quéntar Reservoir. All three essential
Pharmacological activity of the essential oil of Bupleurum gibraltaricum: anti-inflammatory activity and effects on isolated rat uteri.
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The essential oil of Bupleurum gibraltaricum showed considerable anti-inflammatory activity against carrageenan-produced pedal edema in rats. This appeared to be due to the delta-3-carene component. The essential oil and delta-3-carene both produced qualitatively similar changes in rat uterine
Anti-inflammatory activity of the essential oil of Bupleurum fruticescens.
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The essential oil of Bupleurum fruticescens was investigated qualitatively and quantitatively by GC and GC-MS analyses. The anti-inflammatory activity of the whole essential oil and its major components was also investigated in the rat hindpaw edema model induced by carrageenin or by PGE1. The
["Dose-time-toxicity" relationship study on hepatotoxicity caused by multiple dose of total Bupleurum saponin crude extracts to rats].
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OBJECTIVE
To study the time-toxicity and dose-toxicity relationships caused by multiple dose of total Bupleurum saponin extracts to rats.
METHODS
Rats were picked according to different time or dose points, and total Bupleurum saponin crude extracts were administered to rats. The death circumstance
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