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Effects of caffeine and theophylline on the development of dental caries in rats.

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The purpose of this study was to evaluate the influence of caffeine and theophylline on the development of dental caries in rats. Six Wistar dams (spf), mutans streptococci free, were obtained, each with six male pups. The dams were infected by Streptococcus sobrinus 6715 and divided into three

STUDIES IN EDEMA : VIII. THE INFLUENCE OF CAFFEINE ON ABSORPTION FROM THE PERITONEAL CAVITY AND THE INFLUENCE OF DIURESIS ON EDEMA.

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I. In normal animals the injection of caffeine slightly diminishes the absorption of fluid from the peritoneal cavity, in spite of the fact that the amount of fluid and sodium chloride eliminated through the kidneys is markedly increased. The lessened absorption of fluid is due to a slight lowering

Configurational studies of complexes of tea catechins with caffeine and various cyclodextrins.

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A suspension of an equimolecular amount of ENT-gallocatechin-3-O-gallate ( ENTGCg) and caffeine in water afforded two kinds of crystals, which were 1 : 2 and 2 : 2 complexes of ENTGCg and caffeine. The stereochemical structures and intermolecular interactions between ENTGCg and caffeine were

Caffeine-derived N-nitroso compounds. V. Carcinogenicity of mononitrosocaffeidine and dinitrosocaffeidine in bd-ix rats.

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Mononitrosocaffeidine (MNC) and dinitrosocaffeidine (DNC) are new N-nitroso compounds obtained from in vitro nitrosation of caffeidine, a hydrolysis product of caffeine present in a typically made and widely consumed tea from Kashmir (India), a high incidence area of esophageal and stomach cancer.

Low dose caffeine as a salivary tracer for the determination of gastric water emptying in fed and fasted state: A MRI validation study.

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Improving our knowledge about human gastrointestinal physiology and its impact on oral drug delivery is crucial for the development of new therapies and effective drug delivery systems. The aim of this study was to develop an in vivo tool to determine gastric emptying of water by administration of a

Desmoplastic small round cell tumour successfully treated with caffeine-assisted chemotherapy: a case report and review of the literature.

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Desmoplastic small round cell tumour (DSRCT) is a rare tumour, usually arising in the abdominal cavity. DSRCT remains an aggressive malignancy, with a poor prognosis despite multi-modality treatments. In the published literature, there has been no patient who lived for three years or more without

Alteration of ovine fetal respiratory-like activity by diazepam, caffeine, and doxapram.

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The effects of diazepam, caffeine citrate, and doxapram on fetal respiratory-like activity (RLA) were studied in 10 chronic sheep preparations (90 to 130 days' gestation). We define fetal RLA as regular changes in fetal tracheal pressure occurring with a frequency of at least 1 Hz and an amplitude

Evaluation of cardiovascular effects of caffeine using telemetric monitoring in the conscious rat.

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Caffeine (1,3,7 trimethylxanthine) affects the cardiovascular system, with potential toxic effects ranging from a moderate increase in heart rate to more severe cardiac arrhythmias. Telemetry transmitters were implanted in Wistar rats in the peritoneal cavity with a pressure catheter in the aorta

Direct block of human ether-a-go-go-related gene potassium channels by caffeine.

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The human ether-a-go-go-related gene (hERG) potassium channel is expressed in a variety of cell types, including neurons, tumor cells, and cardiac myocytes. In the heart, it is important for repolarization of the cardiac action potential. Attenuation of hERG current can cause long QT syndrome and

Maternal caffeine consumption during pregnancy does not affect preimplantation development but delays early postimplantation growth in rat embryos.

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Models for studying prenatal drug-induced intrauterine growth retardation (IUGR) have, without exception, measured growth-related factors in the postimplantation embryo, fetus or neonate. Therefore, it is not known whether effects of drug exposure on growth and metabolism begin early in the

Adolescent caries: a discussion on diet and other factors, including soft drink consumption.

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It can be summarized that adolescents have unique needs and concerns in regards to dental care. Among these concerns is the adolescent diet, which often contains high amounts of high-carbohydrate snack foods. Popular among these foods are carbonated beverages, usually containing significant amounts

Prolonged caffeine intake decreases alveolar bone damage induced by binge-like ethanol consumption in adolescent female rats

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Ethanol consumption has been reported to negatively impact on periodontal disease. In particular, oral cavity disorders occur upon ethanol exposure during adolescence, a life period associated with particular patterns of short and intense ('binge-like') ethanol consumption that is most deleterious

Renal and metabolic effects of caffeine in obese (fa/fa(cp)), diabetic, hypertensive ZSF1 rats.

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In Western society, the triad of hypertension, metabolic syndrome and obesity (which caries a high risk for renal disease) is increasing, as is the intake of caffeine. However, no information is available regarding the metabolic or renal consequences of caffeine consumption in this complex disease

Inhibition of lung carcinogenesis by black tea in Fischer rats treated with a tobacco-specific carcinogen: caffeine as an important constituent.

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Here, we examined the effect of black tea and caffeine on lung tumorigenesis in F344 rats induced by the nicotine-derived carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in a 2-year bioassay. NNK was administered s.c. at a dose of 1.5 mg/kg body weight three times weekly for 20

Electro-physiological changes in the brain induced by caffeine or glucose nasal spray.

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A direct link between the mouth cavity and the brain for glucose (GLUC) and caffeine (CAF) has been established. The aim of this study is to determine whether a direct link for both substrates also exist between the nasal cavity and the brain. Ten healthy male subjects (age 22 ± 1 years) performed

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