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Leptin Infusion and Endothelial Vasomotor Response
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Introduction High BMI and particularly fat mass index are associated with increased risk of coronary artery disease and other cardiovascular conditions, but the underlying mechanisms are not well understood. Endothelial dysfunction precedes atherosclerosis and represents an important link between
Exercise and Diet Intervention Attenuated Inflammation Through ASC Gene and Inflammatory Markers in Obese Adults
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A randomized clinical trial was conducted in the Institute of Translational Nutrigenetics and Nutrigenomics, Department of Molecular Biology in Medicine, Health Sciences Center, at the University of Guadalajara, Guadalajara, Jalisco, Mexico, from February of 2018 to February of 2019. All
Optimal Reduction in SB to Reduce Glycemic Variability
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This study will be a randomized crossover trial and reported in accordance with CONSORT guidelines. The study will involve a total of three seven-day conditions (2 experimental and 1 control) with a three-week washout period in-between to minimize practice effects for a total intervention period of
Myotonic Dystrophy Type 1 Aerobic Exercise Study
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The present study is a repeated measures design, with sampling of the cohorts on two separate occasions. Upon obtaining informed consent, participants will be assigned into one of two groups:
Group 1: DM1 Exercise Group DM1 diagnosed, physically inactive males, n = 6 DM1 diagnosed, physically
Memory-Updating Technique to Reduce Food Craving and High Calorie Food Intake Among Individuals With Overweight/Obesity
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Participants (N=150) with overweight/obesity (body mass index ≥25.0 kg/m^2) will be recruited locally via media outlets, flier postings, and local research registries to participate in a novel laboratory-based intervention to attenuate craving for and intake of high calorie foods. Interested
Essential Amino Acids and High Intensity Interval Training
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Assessing the Effectiveness of an N-of-1 Platform Using Study of Cognitive Enhancers
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The growing burden of chronic disease in the U.S. and the economics of accountable care are driving a shift toward proactive approaches to disease prevention and health maintenance. At the same time, precision medicine studies continue to reveal substantial heterogeneity in the manifestations of
Effects of Exergame in Patients at High Cardiovascular Risk.
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Introduction Cardiovascular (CV) disease is a major cause of premature death and morbidity worldwide. It is widely known that age, sex, hypertension, dyslipidemia, diabetes, and smoking are the main risk factors which can cause CV disease[1]. Many other CV risk factors and their markers have been
The Effects of Chronic Exercise on UCP1 Gene in Human White Adipose Tissue
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The investigators obtained three (baseline, post-exercise, post-de-training) subcutaneous fat biopsies from 32 healthy men who undertook three different eight week exercise programs [aerobic (9 participants), resistance (8 participants), combined (aerobic+resistance, 8 participants)] and a
Reducing Sugar-sweetened Beverage Consumption Among Children
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Sugar-sweetened beverages (SSBs) significantly contribute to sugar and calorie intakes, and their consumption is associated with metabolic disease. Sweetened beverages also account for the majority of pediatric caffeine consumption. It is well-established that habitual caffeine use leads to
Exergaming Improves Executive Functions in Patients With Metabolic Syndrome
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Introduction In recent years, the relationship between cognitive function and metabolic syndrome has been widely studied. Metabolic syndrome (MetS) has been shown to be associated with a decline in executive function due to multiple risk factors, including hypertension, dyslipidemia, impaired
Gastric Emptying - Implications for the Pathogenesis of Type 2 Diabetes
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Background It is recognized that there are differences between ethnic groups in the risk of developing type 2 diabetes (T2D), but the underlying pathophysiology remains poorly defined. For example, whilst insulin resistance, exacerbated by obesity, is common in Caucasian, Hispanic and South Asian
Effect of Oral Feeding on Gastric Emptying, Gut Blood Flow, and Hormone Responses in Obese and Healthy Weight Subjects
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The World Health Organisation (WHO) has deemed being overweight or obese as the fifth leading cause for global deaths, with more than 1.9 billion adults being defined as overweight, and 600 million defined as being obese. Conditions associated with obesity, such as stroke, type 2 diabetes, certain
Evaluation of a Supplement for Weight Management in Obese and Overweight Individuals
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The present study is a randomized double-blind placebo controlled repeated measures design, with sampling of the cohorts on five separate occasions.
Group 1: Intervention Group (n = 24) Healthy, overweight or obese physically inactive males, supplement, n = 12 Healthy, overweight or obese physically
FES Cycling and Nutritional Counseling for Battling Obesity After SCI
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Obesity prevalence among individuals with SCI is about 66%. However, when the BMI formula is adjusted for the loss of muscle after SCI, the combined overweight and obesity rate is 70 to 75%. This places the SCI population across the U.S. at the top of the list in terms of obesity. Additionally,
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