Patients will be randomized to self treat with 2 g of VM1001 cream times daily for ten days, have a five day wash out period and then 10 days of self treatment with the comparator.

Patients will be randomized to self treat with either active product or placebo comparator thrice daily for 10 days followed by a 5 day wash out period then 10 days of experimental treatment thrice daily for 20 days.

Treatment of PHN

3VM1001

Cream without investigational drug. Self treatment 3 times daily for 10 days

Placebo

Medex Healthcare Research, Inc.

Medex Healthcare Reasearch, Inc.

3VM1001 Cream for the Treatment of Pain Associated With Post Herpetic Neuralgia (PHN)

A Double-Blind, Placebo-Controlled, Crossover Study to Evaluate the Efficacy and Tolerability of 3VM1001 Cream for the Treatment of Pain Associated With Post-Herpetic Neuralgia: A Proof of Concept Study

The time averaged mean of all patient pain scores over each study period; trend over time for each treatment sill be assessed by day of therapy to evaluate any increase or decrease in effect for each study treatment.

Collection of adverse events and the number of subjects discontinuing he study

This measure is a single-item rating by participants of their improvement with treatment on a 7-point sale that ranges from "very much improved" to very much worse" with "no change "the mid-midpoint".

Patient Global Assessment of Treatment Satisfaction from baseline to the end of each study phase. Patients will rate their overall satisfaction with study treatment using a 5-point categorical scale.

recording of the use of rescue mediation at each phase of the study.

CDA Research Group, Inc.

Double-blind, Placebo-controlled, Crossover study to evaluate treatment and tolerability of the experimental product for treatment of post herpetic pain.

Subjects will be randomized to receive either treatment wih 3VM1001 cream or the comparator daily for 10 days followed by 5 day wash out period before 10 days of treatment with the comparator or investigational treatment, .

healthy controls without asthma or other respiratory disease.

The clinical grade of asthma is assessed in terms of the type of current asthma control (as GEMA Guide 4.0)

Asthma

Analysis of the heart rate variability with an electrocardiogram with a commercial device adapted to asthmatic patients using 12 leads, a respiratory band and a pulseoximeter.

EKG (electrocardiogram)

Lorena Soto-Retes

Autonomic Nervous System Role in Uncontrolled ASTHMA and the Paucigranulocitic Phenotype

Comparison of heart rate variability (HRV) through an EKG among the group of non-inflammatory asthma (paucigranulocitic) with the rest of inflammatory phenotypes of severe asthma analyzed.

Stress will be evaluated with validated questionnaires. Hospital Anxiety and Depression Scale (HADS)

Blood determination of glucose (mg/dl) as biomarker of emotional stress in patients with severe uncontrolled asthma.

Blood determination of copeptin (pmol/L) as biomarker of emotional stress in patients with severe uncontrolled asthma.

Blood determination of prolactin (ng/mL) as biomarker of emotional stress in patients with severe uncontrolled asthma.

Salivary determination of cortisol (ng/ml) as biomarker of emotional stress in patients with severe uncontrolled asthma.

Salivary determination of alpha-amylase U/L as biomarker of emotional stress in patients with severe uncontrolled asthma.

Urine cortisol (mcg/24h) as biomarker of emotional stress in patients with severe uncontrolled asthma.

Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau

Universidad de Zaragoza

Capsaicin cream applied to cervix after lidocaine gel

Labor Pain

Pregnancy Loss

Labor Induction

capsaicin cream 0.1% 10 ml applied to cervix

capsaicin

Only lidocaine gel will be appled to the cervix

capsaicin/sembap

3VM1001 Cream for the Treatment of Pain Associated With Post Herpetic Neuralgia (PHN)

Autonomic Nervous System Role in Uncontrolled ASTHMA and the Paucigranulocitic Phenotype

Cervical Capsaicin for Labor Induction and Pain Relief

Pain Assessment, Incidence & Nature in Heart Failure

Database tanaman obat terlengkap yang didukung oleh sains