carcinosarcoma/hypoxia

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Validation of the fluorinated 2-nitroimidazole SR-4554 as a noninvasive hypoxia marker detected by magnetic resonance spectroscopy.

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OBJECTIVE Tumor hypoxia is associated with poor prognosis and a more malignant tumor phenotype. SR-4554, a fluorinated 2-nitroimidazole, is selectively bioreduced and bound in hypoxic cells. We present validation studies of SR-4554 as a noninvasive hypoxia marker detected by fluorine-19 magnetic

Pre-clinical Positron Emission Tomography Reconstruction Algorithm Effect on Cu-64 ATSM Lesion Hypoxia.

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OBJECTIVE Application of distinct positron emission tomography (PET) scan reconstruction algorithms can lead to statistically significant differences in measuring lesion functional properties. We looked at the influence of two-dimensional filtered back projection (2D FBP), two-dimensional ordered

True hypopharyngeal carcinosarcoma: a case report and literature review.

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Objective Carcinosarcoma consists of carcinomatous and sarcomatous tissues and is an aggressive malignant tumor. It is rarely reported in the hypopharynx. Methods A 72-year-old man presented with dysphagia and dyspnea. Laryngoscopy, computed tomography (CT), and 18F-fluorodeoxyglucose positron

TGFβ-pathway is down-regulated in a uterine carcinosarcoma: a case study.

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Data assessing the role of various genetic alterations in uterine carcinosarcoma (CS), particularly the transforming growth factors-β (TGFβ) that play a crucial role in many cellular processes, including proliferation, differentiation, adhesion and migration, are scarce. TGFβ exert their effects

In vitro and in vivo evaluations of a hydrophilic 64Cu-bis(thiosemicarbazonato)-glucose conjugate for hypoxia imaging.

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A water-soluble glucose conjugate of the hypoxia tracer 64Cu-diacetyl-bis(N4-methylthiosemicarbazone) (64Cu-ATSM) was synthesized and radiolabeled (64Cu-ATSE/A-G). Here we report our initial biological experiments with 64Cu-ATSE/A-G and compare the results with those obtained for 64Cu-ATSM and

[Experimental chemotherapy of malignant tumors in combination with short-term general hypoxia].

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The effect of hypoxy on chemotherapy with emoxyl, 5-fluorouracil and bleomycin which are characterized by different affinities with oxygen has been investigated. In an experiment using 96 rats, each weighing 180 g, subcutaneously inoculated with Walker's carcinosarcoma and carcinoma. PC-1, combined

Influence of hepatic arterial blockage on blood perfusion and VEGF, MMP-1 expression of implanted liver cancer in rats.

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OBJECTIVE To investigate the influence of hepatic arterial blockage on blood perfusion of transplanted cancer in rat liver and the expression of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-1 (MMP-1), and to explore the mechanisms involved in transarterial embolization

Some experimental and methodological experiences on the selective inhibition of blood microcirculation in tumor tissues as the central mechanism of the cancer multistep therapy (CMT).

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Microcirculation is a very sensitive process. Under hyperthermia and/or artificial tissue acidification bloodflow ceased regularly and reproducibly. This bloodflow inhibition imposes seemingly as a consequence of a progressing decrease of blood fluidity. However, blood flowing through irritated

Tumour oxygenation under normobaric and hyperbaric conditions.

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Tumour oxygenation during exposure to normobaric and hyperbaric oxygen was assessed by means of a cryophotometric micromethod and a specially constructed pressure chamber. The tumours investigated were DS-carcinosarcomas implanted subcutaneously into the thigh of Sprague-Dawley rats. The animals

Transient increased expression of VEGF and MMP-1 in a rat liver tumor model after hepatic arterial occlusion.

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OBJECTIVE This study investigates the influence of hepatic arterial occlusion (HAO) on blood perfusion of transplanted cancer in rat's liver, and the expression of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-1 (MMP-1) and explores the mechanisms involved in transcatheter

[Effect high-altitude conditions on the antitumor activity of cyclophosphane and its action on lymphoid tissue cells].

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High-altitude hypoxia inhibits the Walker carcinosarcoma growth in rats and enhances the efficacy of antitumour treatment with cyclophosphane. Under mountain conditions the cyclophosphane toxicity effect on the lymphoid tissue decreased. As a response to cyclophosphane administration the depletion

[Characteristics of the metastatic spread of transplanted tumors under high-altitude conditions].

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The data on nature of metastatic spreading of transplantable animal tumours of the Tien-Shan mountains at an altitude of 3200 m above sea level are reviewed. It is shown that the adaptation of mice with Ehrlich adenocarcinoma is followed by the primary tumour growth inhibition and a two-fold

[18F]Fluoroazomycinarabinofuranoside (18FAZA) and [18F]Fluoromisonidazole (18FMISO): a comparative study of their selective uptake in hypoxic cells and PET imaging in experimental rat tumors.

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The present study compares the uptake of [(18)F]Fluoroazomycinarabinofuranoside ((18)FAZA), a recently developed hypoxia tracer for PET imaging of tissue hypoxia, with an established tracer [(18)F]Fluoromisonidazole ((18)FMISO) both in vitro, using Walker 256 rat carcinosarcoma cells, and in vivo in

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