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Is L-carnitine protective in hypoxic cerebral edema in newborn mice?
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The value of carnitine in the prevention of cerebral edema due to acute severe hypoxia in 38 newborn mice was studied. Twenty-nine animals received normal saline (0.25 ml) or carnitine (16 mmol/kg) intraperitoneally, thirty minutes before exposure to 0% oxygen in inspired air for two minutes. Nine
Carnitine deficiency with cardiomyopathy presenting as neonatal hydrops: successful response to carnitine therapy.
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A small-for-date infant presented at birth with severe non-immune hydrops, cardiac failure, metabolic acidosis and hypoglycaemia. Ultrasonography disclosed a cardiomyopathy. Initial therapy consisting of artificial ventilation, inotropes and diuretics resulted in partial disappearance of oedema
Valproate-associated carnitine deficiency and malignant cerebral edema in the absence of hepatic failure.
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We describe a 27-year-old woman who developed encephalopathy and cerebral edema during treatment of refractory complex partial seizures that included acute administration of valproate (VPA) at a dosage of 35 mg/kg per day. Multiple random VPA levels were within therapeutic range, and results of
[Effects of early supplement of exogenous L-carnitine on renal function in severely scalded rats]
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Objective: To explore the effects of early exogenous L-carnitine supplementation on renal function in severely scalded rats. Methods: According to the random number table, sixty-six adult female Sprague-Dawly rats were divided into healthy control group (n=6), scald alone group
Carnitine treatment for stroke in rats.
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Changes in the concentrations of carnitine, long-chain acylcoenzyme A, and long-chain acylcarnitine in ischemic myocardium parallel those in ischemic brain. Since carnitine treatment reverses these changes and improves function in ischemic hearts, we examined whether carnitine given to rats before
Nifedipine toxicity is exacerbated by acetyl l-carnitine but alleviated by low-dose ketamine in zebrafish in vivo.
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Calcium channel blocker (CCB) poisoning is a common and sometimes life-threatening emergency. Our previous studies have shown that acetyl l-carnitine (ALCAR) prevents cardiotoxicity and developmental toxicity induced by verapamil, a CCB used to treat patients with hypertension. Here, we tested
The histopathologic effects of L-carnitine in Sodium Taurocholate Induced Severe Pancreatitis Model.
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OBJECTIVE
To evaluate the histopathologic effects of L-carnitine (LC) in an experimental severe pancreatitis (SP) model induced with sodium taurocholate (STC).
BACKGROUND
LC is an amino acid-like molecule that plays an active role in transporting fatty acids and producing Acetyl CoA in mitochondrial
Nonimmune hydrops fetalis in the liveborn: series of 32 autopsies.
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Nonimmune hydrops fetalis (NIHF) or generalized soft tissue edema and cavity effusions may be due to cardiovascular diseases, congenital infections, genitourinary malformations, thoracic masses, placental conditions, chromosomal abnormalities, and idiopathic. We report 32 cases of NIHF from among
Therapeutic Potential of Novel Twin Compounds Containing Tetramethylpyrazine and Carnitine Substructures in Experimental Ischemic Stroke.
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Although studies have seen dramatic advances in the understanding of the pathogenesis of stroke such as oxidative stress, inflammation, excitotoxicity, calcium overload and apoptosis, the delivery of stroke therapies is still a great challenge. In this study, we designed and synthesized a series of
L-carnitine protection in ammonia intoxication. Effect of aminocarnitine on carnitine-dependent metabolism and acute ammonia toxicity.
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Intraperitoneal administration of L-carnitine (16 mmol/kg) was reported by O'Connor et al. (FEBS Lett 166: 331-334, 1984) to fully protect mice from ammonium acetate given at a dose that kills 100% of untreated controls. Other investigators either have failed to observe protection by L-carnitine or
Fulminant encephalopathy with marked brain edema and bilateral thalamic lesions.
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We encountered two children with acute encephalopathy associated with unique clinical manifestations. Both the patients had status epilepticus at onset and neuroimaging studies revealed marked brain edema and bilateral thalamic lesions. Although they were treated with steroids and immunoglobulin,
Evaluation of the therapeutic efficacy of L-carnitine in congestive heart failure.
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To evaluate the therapeutic efficacy of L-carnitine in elderly subjects suffering from heart failure, secondary to ischemic and/or hypertensive heart disease, 38 patients (22 men, 16 women) were studied, aged from 65 to 82 years. In addition to traditional therapy (digitalis, diuretics,
L-carnitine reduces acute lung injury in experimental biliary obstruction.
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OBJECTIVE
To investigate the protective effects of L-carnitine (LC) on lungs in an experimental obstructive jaundice (OJ) model.
METHODS
This was conducted for 2 months between May 2011 and July 2011 at Suleyman Demirel University School of Medicine Experimental and Clinical Research Center,
Gamma-irradiation-induced testicular oxidative stress and apoptosis: Mitigation by l-carnitine
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The current study evaluated the potential ameliorative and protective impacts of l-carnitine (L-CAR) against γ-irradiation (RAD)-induced oxidative stress and apoptosis in mice testes. Male Swiss mice were allocated into four groups (n = 7). Group 1 served as a control that received saline
Acquired encephalopathy associated with carnitine deficiency after cefditoren pivoxil administration.
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We describe a 47-year-old woman who presented with palinopsia and subacute altered mental change after cefditoren pivoxil administration. The patient showed characteristic clinical manifestations of hypocarnitinemia, which affected her state of consciousness and she had radiologic findings that
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