The study supplementation will be introduced in the daily diet according to the participant preference to a total of 27g of Aleurone/day. One bread bun (35 g) contains 4.8 g Aleurone; one biscuit (15 g) contains 4 g Aleurone; 36 g of RTE cereals contain 9 g Aleurone.

The study supplementation will be introduced in the daily diet according to the participant preference to a total of 27g of Hemicellulose/day. One bread bun (35 g) contains 4.8 g Hemicellulose; one biscuit (15 g) contains 4 g Hemicellulose; 36 g of RTE cereals contain 9 g Hemicellulose. Placebo products contain the same levels of cellulose in place of aleurone's dietary fiber content.

Overweight

Healthy Subjects

Aleurone

Placebo

Fondazione Edmund Mach -Centro Ricerca ed Innovazione

Unità di Dietetica e Nutrizione Clinica, Ospedale S. Chiara, Via Orsi 1

Measuring the Impact of Dietary Supplementation With a High Fiber, High Antioxidant Aleurone on Biomarkers of Cardiovascular Disease and Gut Microbiota in Adults With High Body Mass Index

Change in total plasma homocysteine between timepoints week 2 (baseline) and week 6 (end of dietary supplementation).

plasma metabolites related to homocysteine metabolism (including betaine, dimethylglycine, methionine, choline, folate, riboflavin, vitamin B6).

MS analysis of metabolites related to microbial metabolism.

Faecal microbiota analysis by FISH, qPCR and 454 Roche pyrosequencing

MS analysis of fecal bile acid and fecal sterol concentrations

plasma and urine MS based metabolite profiling;
total cholesterol, triglycerides, LDL-, and HDL-cholesterol levels;
serum glucose and insulin levels;
anthropometric indices;
urinary isoprostane levels;
markers of intestinal permeability in plasma;
C-reactive protein levels as marker of inflammation

Francesca Fava

Fondazione Edmund Mach

Cargill R&D Centre Europe, Havenstraat 84, 1800 Vilvoorde, Belgium

Azienda Provinciale per i Servizi Sanitari della Provincia Autonoma di Trento

The group who receive spironolactone, the dose employed will be 25 mg each other day and titrated to 25 mg daily according to potassium.

Renal Failure

Spironolactone

Hospital of the Medical School of Botucatu

Effects of Spironolactone in Dialysis

Assessment of the Effects of the Combination of Spironolactone to Conventional Pharmacotherapy in Dialysis Patients

The reduction of left ventricular hypertrophy will be measured by echocardiography, blood pressure monitoring residential and pulse wave velocity.

Measurement of serum potassium and other routine laboratory parameters pertaining to the hemodialysis unit of the Hospital of the Medical School of Botucatu - UNESP.

Greicy Mara Mengue Feniman De Stefano

UPECLIN HC FM Botucatu Unesp

Systemic Lupus Erythematosus

Methotrexate and folic acid

University Health Network

Study of Methotrexate in Lupus Erythematosus

A Canadian Multicenter, Randomized, Double-Blind Placebo-Controlled Study of Methotrexate and Folic Acid in Systemic Lupus Erythematosus: A Phase III Trial.

cellulose/infark

Measuring the Impact of Dietary Supplementation With a High Fiber, High Antioxidant Aleurone on Biomarkers of Cardiovascular Disease and Gut Microbiota in Adults With High Body Mass Index

Effects of Spironolactone in Dialysis

Study of Methotrexate in Lupus Erythematosus

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