Plasmodium Vivax

efficacy of chloroquine for the treatment of Plasmodium vivax infections

Chloroquine

Chu R Cam

Evaluating the Efficacy of Chloroquine for the Treatment of Plasmodium Vivax Infections in Central Vietnam

This outcome will be measured at day42 of follow-up. Treatment outcomes such as ACPR, early or late clinical failures are defined following WHO guidelines;

Individual and mean IC50 and IC90 values will be computed for each drug using the IVART tool available online (http://www.wwarn.org/tools-resources/toolkit/analyse/ivart)

asexual parasite forms will be detected by qPCR. This outcome will be measured for each sampling time point.

All parasites at day0 will be genotyped and processed by whole genome sequencing to identify molecular markers of CHL resistance. The same analysis will be done for any P. vivax recurrence occurring during the 42-day follow-up.

All patients will be tested for G6PD deficiency by a rapid test (CareStart) before given the radical cure treatment with primaquine.

sexual parasite forms will be detected by RT-qPCR. This outcome will be measured for each sampling time point.

G6PD allelic variants will be assessed by allele-specific qPCR assay

National Institute of Malariology, Parasitology and Entomology, Vietnam

Institute of Tropical Medicine, Belgium

Study treatment will consist of BCP, three 1.2 g oral tablets (equivalent to 600 mg of BCP each) for 4 weeks, from cows immunized to insulin. Patients will be followed for safety monitoring for an additional 4 weeks.

Nonalcoholic Steatohepatitis

Fatty Liver Disease

Bovine colostrum powder

Liver Unit, Hadassah, Ein Kerem

Bovine Colostrum for Patients With Non Alcoholic Fatty Liver Disease

Gadi Lalazar

Hadassah Medical Organization

the reduced-osmolarity WHO-ORS without Benefiber.

Cholera

Benefiber

Benefiber (50 g/L)-supplemented, reduced-osmolarity WHO-ORS

cellulose/muntah

Evaluating the Efficacy of Chloroquine for the Treatment of Plasmodium Vivax Infections in Central Vietnam

Bovine Colostrum for Patients With Non Alcoholic Fatty Liver Disease

Efficacy of Benefiber-Added, Reduced-Osmolarity WHO-ORS in the Treatment of Cholera in Adults

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