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chagas disease/protease

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Cysteine protease inhibitors for the treatment of parasitic diseases

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BACKGROUND OF THE INVENTION Several parasites responsible for mammalian diseases are dependent on cysteine protease for various life-cycle functions Inhibition of these proteases can be useful in the treatment and/or prevention of these parasitic diseases, see Lecaille, F., et al, Chem. Rev., 102,

Inhibitors of cruzipain and other cysteine proteases

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THIS INVENTION relates to compounds which are inhibitors of the protease cruzipain, a gene product of the Trypanosoma cruzi parasite. In particular, the invention provides compounds that are useful for the therapeutic treatment of Trypanosoma cruzi infection, to the use of these compounds, and to

Inhibitors of cruzipain and other cysteine proteases

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THIS INVENTION relates to compounds which are inhibitors of the protease cruzipain, a gene product of the Trypanosoma cruzi parasite. In particular, the invention provides compounds that are useful for the therapeutic treatment of Trypanosoma cruzi infection, to the use of these compounds, and to

Inhibitors of cruzipain and other cysteine proteases

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This invention relates to compounds which are inhibitors of the protease cruzipain, a gene product of the Trypanosoma cruzi parasite. In particular, the invention provides compounds that are useful for the therapeutic treatment of Trypanosoma cruzi infection, to the use of these compounds, and to

Synthesis and use of .alpha.-ketoamide derivatives and arrays

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FIELD OF THE INVENTION The invention relates to non-peptidic .alpha.-ketoamide compounds and molecular arrays of potential protease inhibitors and the uses thereof. BACKGROUND OF THE INVENTION Proteolytic enzymes, or proteases, are proteins that catalyze the degradation of peptide bonds in protein

Synthesis and use of .alpha.-ketoamide derivatives and arrays

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FIELD OF THE INVENTION The invention relates to non-peptidic .alpha.-ketoamide compounds and molecular arrays of potential protease inhibitors and the uses thereof. BACKGROUND OF THE INVENTION Proteolytic enzymes, or proteases, are proteins that catalyze the degradation of peptide bonds in protein
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