6 hasil
BACKGROUND OF THE INVENTION
Several parasites responsible for mammalian diseases are dependent on cysteine protease for various life-cycle functions Inhibition of these proteases can be useful in the treatment and/or prevention of these parasitic diseases, see Lecaille, F., et al, Chem. Rev., 102,
THIS INVENTION relates to compounds which are inhibitors of the protease cruzipain, a gene product of the Trypanosoma cruzi parasite. In particular, the invention provides compounds that are useful for the therapeutic treatment of Trypanosoma cruzi infection, to the use of these compounds, and to
THIS INVENTION relates to compounds which are inhibitors of the protease cruzipain, a gene product of the Trypanosoma cruzi parasite. In particular, the invention provides compounds that are useful for the therapeutic treatment of Trypanosoma cruzi infection, to the use of these compounds, and to
This invention relates to compounds which are inhibitors of the protease cruzipain, a gene product of the Trypanosoma cruzi parasite. In particular, the invention provides compounds that are useful for the therapeutic treatment of Trypanosoma cruzi infection, to the use of these compounds, and to
FIELD OF THE INVENTION
The invention relates to non-peptidic .alpha.-ketoamide compounds and molecular arrays of potential protease inhibitors and the uses thereof.
BACKGROUND OF THE INVENTION
Proteolytic enzymes, or proteases, are proteins that catalyze the degradation of peptide bonds in protein
FIELD OF THE INVENTION
The invention relates to non-peptidic .alpha.-ketoamide compounds and molecular arrays of potential protease inhibitors and the uses thereof.
BACKGROUND OF THE INVENTION
Proteolytic enzymes, or proteases, are proteins that catalyze the degradation of peptide bonds in protein