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9 hasil
Inhibition of intestinal motility by anandamide, an endogenous cannabinoid.
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The endogenous cannabinoid ligand anandamide (arachidonylethanolamide) inhibited the intestinal passage of a charcoal meal when administered s.c. in mice at doses ranging from 0.1 to 50 mg/kg. This effect was prevented by the cannabinoid CB1 receptor antagonist SR141716A
The effect of cannabinoids on intestinal motility and their antinociceptive effect in mice.
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1. After oral administration to mice, pethidine, Delta(8)-tetrahydrocannabinol (THC), Delta(9)-THC, a cannabis extract and cannabinol had a dose-dependent antinociceptive effect when measured by the hot-plate method. Cannabidiol was inactive at 30 mg/kg. Delta(8)-THC, Delta(9)-THC and pethidine did
Parental cannabis abuse and accidental intoxications in children: prevention by detecting neglectful situations and at-risk families.
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OBJECTIVE
Cannabis intoxication in toddlers is rare and mostly accidental. Our objectives were to focus on the characteristics and management of children under the age of 6 years who were admitted to our emergency department with cannabis poisoning reported as accidental by parents, and to point out
The dual effect of cannabinoid receptor-1 deficiency on the murine postoperative ileus.
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BACKGROUND
Intestinal inflammatory responses play a critical role in the pathogenesis of postoperative ileus (POI). As cannabinoid receptor-1 (CB1) is involved in inhibiting gastrointestinal (GI) motility and anti-inflammation, we aimed to explore its contribution to POI.
METHODS
Experimental POI
In Vitro Propagation of Cannabis sativa L. and Evaluation of Regenerated Plants for Genetic Fidelity and Cannabinoids Content for Quality Assurance.
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Cannabis sativa L. (Marijuana; Cannabaceae), one of the oldest medicinal plants in the world, has been used throughout history for fiber, food, as well as for its psychoactive properties. The dioecious and allogamous nature of C. sativa is the major constraint to maintain the consistency in chemical
Successful treatment of a severe cannabinoid toxicity using extracorporeal therapy in a dog.
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Cannabinoid type 1 receptor modulates intestinal propulsion by an attenuation of intestinal motor responses within the myenteric part of the peristaltic reflex.
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Cannabinoid-1 (CB1) receptor activation affects gastrointestinal propulsion in vivo. It was our aim to further characterize the involved myenteric mechanisms in vivo and in vitro. In CB1(-/-) mice and wild-type littermates we performed in vivo transit experiments by charcoal feeding and in vitro
Involvement of cannabinoid-1 and cannabinoid-2 receptors in septic ileus.
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BACKGROUND Cannabinoid (CB) receptors are involved in the regulation of gastrointestinal (GI) motility under physiological and pathophysiological conditions. We aimed to characterize the possible influence of CB(1) and CB(2) receptors on motility impairment in a model of septic ileus. METHODS
Cannabis, tobacco and domestic fumes intake are associated with nasopharyngeal carcinoma in North Africa.
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BACKGROUND
The lifestyle risk factors for nasopharyngeal carcinoma (NPC) in North Africa are not known.
METHODS
From 2002 to 2005, we interviewed 636 patients and 615 controls from Algeria, Morocco and Tunisia, frequency-matched by centre, age, sex, and childhood household type (urban/rural).
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