A group of participants that will be using toothpaste without tooth whitening ingredients.

A group of participants that will be using urea peroxide whitening toothpastes.

A group of participants that will be using hydrogen peroxide whitening toothpastes.

A group of participants that will be using whitening toothpastes that contain abrasive ingredients.

A group of participants that will be using whitening toothpastes that contain enzymes as whitening ingredients.

A group of participants that will be using toothpastes that contain an activated charcoal.

Teeth Whitening

A sample of cells from the buccal mucosa area will be taken with cytological sampling brush and will be fixed on on a microscopy slide and stained with a Feulgen fast green solution. The samples will be analyzed by electron microscopy. Tooth color will be measured, verified and evaluated with a Vita Easyshade V digital spectrophotometer in initial phase, after one month of usage, after two months of usage and one month after the end of usage.
Before using any of the whitening toothpaste under test, every participant will use non whitening toothpaste for one month, twice a day.
Satisfaction and impression with treatment will be recorded with the questionnaires provided for this study.

Control group

Whitening toothpaste 1

Whitening toothpaste 2

Whitening toothpaste 3

Whitening toothpaste 4

Whitening toothpaste 5

School of the Medicine, University of Split

Tooth Whitening Evaluation With Cytotoxic and Genotoxic Effect of Commercial Whitening Toothpastes on Oral Mucosal Cells

The following measurements were will be recorded: L*,a*, b* values for all teeth as well as the tooth shade. The color was will be established by CIELAB color space. ΔE is will be calculated using the following formula: ΔE=√(〖(ΔL*)〗^2+〖(Δa*)〗^2+〖(Δb*)〗^2 ). The color changes between the evaluation times in each tested group and between groups were will be analysed using the ΔE, ΔL*, Δa* and Δb*values. To calculate the difference in tooth shade according to the Vita Classical scale, the recorded values were will be ordered in scores from 1 to 16 in a luminosity sequence.

Assessment of biocompatibility through cytotoxicity and genotoxicity parameters of commercially available toothpastes with whitening effect will be performed using micronucleus assay.

Assessment of participant's satisfaction with treatment and used toothpaste will be performed by prepared questionnaire for the study. Respondents will complete a questionnaire of eating and living habits, too

Assessment of participant's satisfaction with treatment and used toothpaste will be performed by prepared questionnaire for the study.

Nada Zorica Vladislavic

University of Zagreb

The study is randomized, prospective clinical trial.

• Pemetrexed and cisplatin will be admixed together in 1 liter of normal saline. The admixture of pemetrexed/cisplatin is stable for 4 hours and should be prepared and delivered immediately before use in the OR. The length of the pemetrexed/cisplatin lavage will be 1 hour.

charcoal/karies gigi

Tooth Whitening Evaluation With Cytotoxic and Genotoxic Effect of Commercial Whitening Toothpastes on Oral Mucosal Cells

Study of Cytoreductive Surgery and Hyperthermic Intraoperative Chemotherapy With Pemetrexed and Cisplatin for Malignant Pleural Mesotheliomas

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