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Levamisole as an immunoadjuvant: phase I study and application in breast cancer.
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A phase I study of levamisole in patients with cancer was undertaken to determine its therapeutic dose range, side effects, limiting toxicity, and influence on immune function. Simultaneously, a group of patients receiving adjuvant combination chemotherapy for carcinoma of the breast were entered in
Long-term prospective trial of low-dose methotrexate in rheumatoid arthritis.
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Twenty-six patients with severe rheumatoid arthritis who had completed a randomized crossover trial of methotrexate elected to continue to receive the drug in a long-term prospective study. At 36 months, 16 patients remained in the study. Over this period of time, significant improvement was noted
Arginine stimulates lymphocyte immune response in healthy human beings.
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The effect of daily dietary supplements of 30 gm of arginine HCl for 7 days on peripheral blood lymphocyte (PBL) mitogenic reactivity in vitro was measured in 21 healthy human volunteers. Arginine significantly increased stimulation indices of PBL following concanavalin A (Con A) (57.9 +/- 11.4
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