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cryptosporidiosis/diare

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Treatment of Cryptosporidiosis

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Background: Reports from longitudinal birth cohort study at Bangladesh show that 77% of children experience at least one incidence of cryptosporidiosis in the first two years of life. Cryptosporidiosis is also associated with the development of malnutrition leading to an estimate of an additional

Parasitic Causes of Secretory Diarrhea in Children and Chronically Ill Adult.

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Secretory diarrhea has many causes as infection with bacteria, viruses or protozoa. It results from increased chloride secretion, decreased sodium absorption, or increased mucosal permeability . Parasitic pathogens induce Secretory diarrhea as they infect and damage the absorptive villus tips,

Field Studies of Amebiasis in Bangladesh

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Entamoeba histolytica infection results from ingestion of the cyst of Entamoeba histolytica from fecally-contaminated food or water. Local invasion results in amebic dysentery and metastasis to amebic liver abscess. The diagnosis of intestinal amebiasis is ideally made using an E.

Trial of Ceramic Water Filters to Reduce Cryptosporidium Infection in Kenya

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Diarrhea is a major cause of illness among children in Africa. Cryptosporidium is a protozoan waterborne diarrheal pathogen resistant to chlorine. Ceramic filters are effective at improving drinking water quality, including removal of protozoa. In a recent preliminary analysis of >22,000 children <5

Pharmacotherapy for HIV+ Stimulant Dependent Individuals

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In 1996, the use of protease inhibitors and triple therapy known as HAART (highly active antiretroviral therapies) became widespread in the United States for the treatment of HIV. This changed the disease process from a relentless and progressive one to a chronic one, with the resulting need to

Interleukin 12 (IL-12) for the Treatment of Cryptosporidiosis in AIDS Patients

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Cryptosporidium parvum can cause chronic diarrhea and biliary disease in people with AIDS, resulting in significant morbidity and mortality. Highly effective antiparasitic treatment for this infection is not currently available. Paromomycin and azithromycin have some efficacy and have been used in

Nitazoxanide for the Treatment of Chronic Diarrhea in HIV Infected Children

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C. parvum is a significant opportunistic infection in much of the developing world, where children may not have access to highly active antiretroviral therapy. There is currently no established therapy for chronic cryptosporidiosis in HIV infected children. The FDA has approved NTZ for the treatment

Treatment of Chronic Cryptosporidiosis in AIDS Patients

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Cryptosporidium parvum, an intracellular protozoan parasite, is a frequent cause of chronic diarrhea in HIV-infected patients, causing significant morbidity and mortality. Highly effective antiparasitic treatment for this infection is not currently available. Paromomycin and azithromycin have some

The Effectiveness of Cow's Milk Immune Globulin in the Treatment of AIDS-Related Diarrhea

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Protocol For the Treatment of Cryptosporidiosis in AIDS Patients With Diclazuril (R64,433)

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A Study to Evaluate the Use of Nitazoxanide to Treat Cryptosporidiosis

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Patients receive oral nitazoxanide daily for 14 days, after which those with complete clinical and parasitologic response discontinue treatment. Non-responders and partial responders may continue therapy for an additional 14 days at the discretion of the physician. Non-responders who show signs of

A 28-Day Study of Diclazuril in the Treatment of Cryptosporidiosis in Patients With AIDS

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A Study of Nitazoxanide in Patients With AIDS and Diarrhea Caused by Cryptosporidium

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There is no proven therapy for cryptosporidiosis in persons with AIDS. Nitazoxanide appears to be a good candidate drug for further evaluation because of its effectiveness in preclinical models, the data from early clinical trials and its safety profile. Cooperation between clinical researchers and
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