The first group will receive Minoxidil 5% topically twice daily for 4 months.

The second group will receive NAC orally 600 mg 3 times a day for 4 months.

The third group will receive combined treatment of Minoxidil 5% twice daily and oral NAC 600 mg 3 times a day for 4 months.

The fourth group will be the patients who are refusing the treatment and will be followed-up over 4 months.

Androgenetic Alopecia

Topical 5% Minoxidil and N-Acetyl-Cysteine 600 mg orally

Minoxidil 5% topically and oral NAC 600 mg

dermatology clinics in Ain Shams University Hospital and Kafr El Sheik University Hospital.

N-Acetyl-Cysteine for Treatment of AGA in Men

Efficacy and Tolerability of N-Acetyl- Cysteine for Treatment of The Early-onset Androgenetic Alopecia in Men

A photographic review of the scalp for each patient. Photos were standardized as to subject, area, distance, illumination, angle of exposure and background so that there were no major differences between any of the series of photographs. Photographs were taken using Nikon D3300 AF-P 18-55 VR 24.2 Megapixels® digital camera, based on the grading suggested by Olsen et al.,(2002) graded the photographs on a 7-point scale from dense, moderate, minimal growth, no change, minimal, moderate or dense loss. This was shown at baseline and 16 weeks of the trial.

Images were taken from fixed points in the scalp using the Dermlite П PRO HR® dermoscopy for each patient when they first presented and every month for four months. Digital images of the dermoscopic features were taken by digital camera Nikon D3300 AF-P 18-55 VR 24.2 Megapixels®. The reference points are set to the top of the vertex and a landmark for each frontal region was the intersecting point between lines passing through the ipsilateral tragus and lateral point of eyebrows. Each point was analyzed before and after follow up period by single-blinded expert in trichoscopy looking for the following parameters; total hair count, terminal hair count, vellus hair count, triple or more follicular unit, double follicular unit, single follicular unit, number of perifollicular halo (peripilar sign), thick terminal hair and thin terminal (intermediate) hair. Parameters recorded numerically then statistically analyzed for comparison between different groups of trial.

Patient satisfaction scaled from 0 if unsatisfied, 1 is mild satisfied and 2 if satisfied and compliance with treatment was documented through a patient-filled questionnaire.

Side effects of the drugs (irritation, dandruff, and hypertrichosis for minoxidil plus nausea for NAC) were documented and statistically analyzed for comparison between groups of trial.

Mohamed Abo Shabana Hussein Mohamed

Teaching Assistant of Dermatology and Venereology Department Kafrelsheikh University

Kafrelsheikh University

Ain Shams University

Stratum 1: From 3 months to <18 months= 175 Stratum 2: From 18 months to 59 months= 175
In total, 350 participants will be enrolled

Acute Diarrhea

Half of the tablet (10 mg) for 3 to 6 months old children and one tablet (20 mg) daily for > 6 to 59 months old children. The tablet will be dissolved in a teaspoon of safe water or breast milk and administered once daily for 10 days.

Zinc Sulfate Dispersible Tablet 20 mg (Elemental Zinc 20 mg as Zinc Sulfate Monohydrate / Tablet)

Zinc Sulfate Acceptability

Zinc Sulfate Acceptability Study in Children With Acute Diarrhea: A Prospective, Open-label, Interventional Study

The treatment will be considered to have good acceptability if 80% of the prescribed treatment is taken by at least 70% of the children.

A subjective evaluation measured on the basis of a caregiver's report of his/her child's behavior (through a 5-point pictorial Hedonic scale) during the 10 days when the medicine is administered. A 'Diary Card' will be provided to the caregiver for keeping the daily records of the events.

International Centre for Diarrhoeal Disease Research, Bangladesh

Stratum 1: From 3 months to <18 months= 175 Stratum 2: From 18 months to 59 months= 175
in total, 350 participants will be enrolled

Dietary Supplement: N-Acetyl-Cysteine Phase 4 Study Type: Interventional Study Design: Treatment, Parallel Assignment, Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Randomized, Efficacy Study
Primary Outcome Measure:
Hamilton Depression Rating Scale [Time Frame: baseline, 1, 2, 3 months] [Designated as safety issue: Yes]
Secondary Outcome Measures:
Carbon Oxide exhalation [Time Frame: basal, 1, 2, 3 months] [Designated as safety issue: Yes]
Other Pre-specified Outcome Measures:
Biological outcome measures [Time Frame: baseline and 3 months] [Designated as safety issue: Yes] inflammatory and oxidative stress biomarkers N-Acetyl-cysteine 1800 mg / day will be taken for 12 weeks versus placebo 12 weeks.

Study Type: Interventional Study Design: Treatment, Parallel Assignment, Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Randomized, Efficacy Study
Official Title: Effects of N-Acetyl-Cysteine on Oxidative Stress Biomarkers in Bipolar Patients With and Without Tobacco Use Disorder
Primary Outcome Measure:
Hamilton Depression Rating Scale [Time Frame: baseline] [Designated as safety issue: Yes]
Secondary Outcome Measures:
Carbon Oxide exhalation [Time Frame: basal, 1, 2, 3 months] [Designated as safety issue: Yes]
Other Pre-specified Outcome Measures:
Biological outcome measures [Time Frame: baseline and 3 months] [Designated as safety issue: Yes] inflammatory and oxidative stress biomarkers
Placebo will be taken for 12 weeks.

Bipolar Disorder

drug: N-Acetyl-cysteine N-Acetyl-cysteine 1800 mg a day for 12 weeks versus placebo for 12 weeks

N-Acetyl-Cysteine

departement of medicine - state university of Maringá

State University of Maringá

Efficacy of N-Acetyl-Cysteine in Bipolar Disorder and Tobacco Use Disorder

Effects of N-Acetyl-Cysteine on Oxidative Stress Biomarkers in Bipolar Patients With and Without Tobacco Use Disorder

inflammatory and oxidative stress biomarkers

Mauro Porcu

Professor of Psychiatry

Universidade Estadual de Maringá

Methadone and N-acetylcysteine for opioids abstaining

Opioids Use

Methadone; NAC

Methadone

Taichung Veterans General Hospital

Compare Methadone Combined With N-Acetyl-Cysteine (NAC) and Methadone Alone for Opioids Astaining

Evaluation Whether Higher Retention Rate is in Those of Combined Methadone With N-Acetyl-Cysteine Compared to Those With Methadone Alone During a Six-month Study

cysteine/diare

N-Acetyl-Cysteine for Treatment of AGA in Men

Zinc Sulfate Acceptability

Efficacy of N-Acetyl-Cysteine in Bipolar Disorder and Tobacco Use Disorder

Compare Methadone Combined With N-Acetyl-Cysteine (NAC) and Methadone Alone for Opioids Astaining

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