Treatment of or prophylaxis against the occurrence of pulmonary disorders associated with hypoxemia and/or smooth muscle constriction or infection in the lungs comprises administration into the lung(s) as a gas composition comprising nitric oxide, e.g. ethyl nitrite or nitric oxide, and also administering into the lungs L-cysteine. The pulmonary disorder can be persistent pulmonary hypertension of the newborn to increase SpO2 and decrease systolic blood pressure. In another case administration is to a premature newborn to prophylax against the development of bronchopulmonary dysplasia.

Duke University

Potentiating the effect of compound comprising nitric oxide

Treatment of pulmonary disorders associated with hypoxemia and/or smooth muscle constriction comprises administering into the lungs as a gas a compound with an NO group which does not form NO.sub.2 /NO.sub.x in the presence of oxygen or reactive oxygen species at body temperature. Treatment of cardiac and blood disorders, e.g., angina, myocardial infarction, heart failure, hypertension, sickle cell disease and clotting disorders, comprises administering into the lungs as a gas, a compound which reacts with cysteine in hemoglobin and/or dissolves in blood and has an NO group which is bound in said compound so that it does not form NO.sub.2 /NO.sub.x in the presence of oxygen or reactive oxygen species at body temperature. Exemplary of the compound administered in each case is ethyl nitrite.

Pulmonary delivery of NO group-containing compound in gas form to treat respiratory, cardiac and blood disorders

Treatment of pulmonary disorders associated with hypoxemia and/or smooth muscle constriction and/or inflammation comprises administering into the lungs as a gas compound with an NO group which does not form NO.sub.2 /NO.sub.x in the presence of oxygen or reactive oxygen species at body temperature. Treatment of cardiac and blood disorders, e.g., angina, myocardial infarction, heart failure, hypertension, sickle cell disease and clotting disorders, comprises administering into the lungs as a gas, a compound which reacts with cysteine in hemoglobin and/or dissolves in blood and has an NO group which is bound in said compound so that it does not form NO.sub.2 /NO.sub.x in the presence of oxygen or reactive oxygen species at body temperature. Exemplary of the compound administered in each case is ethyl nitrite.

cysteine/hypoxia

Potentiating the effect of compound comprising nitric oxide

Pulmonary delivery of NO group-containing compound in gas form to treat respiratory, cardiac and blood disorders

Method of treating cardio pulmonary diseases with no group compounds

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