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A Pilot Randomized Controlled Trial of Intravenous N-acetyl Cysteine in STEMI

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Patients presenting with ST-segment elevation myocardial infarction within 3 hours of symptom onset and satisfying all of the inclusion criteria after informed consent would be randomly allocated to either intravenous N-Acetylcysteine or standard treatment using a 1:1 allocation ratio. Those

Vascular and Metabolic Changes in Postmenopausal Diabetics

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Introduction Complications of diabetes, such as cardiovascular disease, are associated with increased mortality among type 2 diabetes mellitus patients. The presence of type 2 diabetes mellitus (T2DM) also increases the relative risk of developing cardiovascular disease in women compared to men .

Effect of Polyvitaminics (Pyridoxine Hydrochloride, Folic Acid and Cyanocobalamin) in the Concentration of Homocysteine and Lipid Profile in Postmenopausal Women: a Randomized Controlled, Double-blind Clinical Trial

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Subjects The study protocol and informed consent was approved by the Ethics Committee of the Hospital Santa Marcelina, Sao Paulo, Brazil (Process nº 09/08, CAAE nº 0016.0.270.000-08).Sixty women (figure 1) were postmenopausal selected from the outpatient Gynecology - Endocrine Hospital Santa

The Recurrence Study

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Patient admitted to the stroke service with acute stroke and TIAs will be eligible for the study. The study will enroll patients at Hamad General Hospital in the setting of the Stroke Ward. The investigators anticipate approximately 300 patients to be enrolled based on the number of strokes that are

Effects of Dietary Amino Acids on Serum and Macrophage Atherogenicity

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Atherosclerosis is the underlying cause of cardiovascular diseases (CVD), the major cause of death worldwide. Atherosclerosis is an inflammatory disease of the arteries in which activated macrophages are abundant in the atherosclerotic lesions. Macrophages play key roles during early atherogenesis.

Safety and Tolerability of Sodium Thiosulfate in Patients With an ACS Undergoing CAG Via Trans-radial Approach.

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Despite the recent advances in treatment, acute myocardial infarction (AMI) frequently results in permanent myocardial injury imposing an increased risk for adverse cardiac remodelling, diminished cardiac function and the development of heart failure. Decreased cardiac function after PPCI is

Sodium Thiosulfate to Preserve Cardiac Function in STEMI

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Introduction and rationale: Despite the recent advances in treatment, acute myocardial infarction (AMI) frequently results in permanent myocardial injury imposing an increased risk for adverse cardiac remodelling, diminished cardiac function and the development of heart failure. Decreased cardiac

IPHAAB-study Influence of Physical Activity on Atherosclerosis Biomarkers

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According to Statistik Austria, cardiovascular disease (CVD) is the most common reason for death in Austria in total population. In 2011, 42,3 % of all deaths were due to CVD (ICD-10 I00-I99). In People aged 45-64 years, CVD is, beyond cancer, the second most common cause of death. According to the

Generation of a Cellular Model of CADASIL From Skin Fibroblasts

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ISCHEMIA-Chronic Kidney Disease Trial

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BACKGROUND: Among patients with advanced CKD, cardiovascular disease is the leading cause of death,15-30 times higher than the age-adjusted cardiovascular mortality rate in the general population. The projected 4-year mortality is >50% in patients with advanced CKD and is worse than that for

The Effect of the Forced Diuresis With Matched Hydration in Reducing Acute Kidney Injury During TAVI

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Reducing Acute Kidney Injury in TAVI Patients (REDUCE trial) The Effect of the Forced Diuresis With Matched Hydration in Reducing Acute Kidney Injury During Transcatheter Aortic Valve Implantation (TAVI) Interventional Cardiology, Department of Cardiology Tel Aviv Medical Center Tel Aviv Sackler

Effects of N-acetyl Cysteine During Percutaneous Coronary Intervention

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Circulating Markers for Ischemic Heart Disease

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Hypotheses, Objectives and Aims: Hypotheses:Caspase-3, cleaved and activated, and dystrophin can be detected in human circulation. The levels of these two markers are elevated during acute myocardial infarction. Furthermore, the levels of these two proteins are greater in those who develop heart

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