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Halaman 1 dari 17 hasil
Method of synthesizing S-allyl-cysteine analogues and their therapeutic application in treating myocardial infarction
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FIELD OF INVENTION
The present invention relates to methods of synthesizing S-allyl-cysteine analogues and their therapeutic composition and applications in treating myocardial infarction.
BACKGROUND OF INVENTION
Myocardial infarction is irreversible necrosis of heart muscle cells caused by ischemic
6-substituted amino-4-oxa-1-azabicyclo [3,2,0] heptan-7-one derivatives as cysteine protease inhibitors
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BACKGROUND OF THE INVENTION
Cysteine proteases, such as cathepsins B, L, S, and O.sub.2, have been implicated in a number of diseases, including cancer metastasis and invasion (Clin. Exp. Metastasis 1992, 10, 145-155; Cancer Metastasis Rev. 1990, 9, 333-352), arthritis (Int. J. Biochem. 1993, 25,
3,4-Disubstituted azetidin-2-one derivatives useful as cysteine proteinase regulators
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BACKGROUND OF THE INVENTION
Cysteine proteinases containing a highly reactive cysteine residue with a free thiol group at the active site have been known as playing an important role in certain conditions distinguished by aberrant protein turnover such as: muscular dystrophy (Am. J. Pathol. 1986,
4-substitued-3-[1 or 2 amino acid residue]-azetidin-2-one derivatives useful as cysteine proteinase inhibitor
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BACKGROUND OF INVENTION
Cysteine proteinases containing a highly reactive cysteine residue with a free thiol group at the active site have been known as playing important role in certain conditions distinguished by aberrant protein turnover such as: muscular dystrophy (Am. J. Pathol. 1986, 122,
4-substituted-3-(2-amino-2-cycloalkyl methyl)-acetamido azetidin-2-one derivatives as cysteine proteinase regulators
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BACKGROUND OF THE INVENTION
Cysteine proteinases containing a highly reactive cysteine residue with a free thiol group at the active site have been known as playing an important role in certain conditions distinguished by aberrant protein turnover such as: muscular dystrophy (Am. J. Pathol. 1986,
4-substituted-3-(2-amino-2-cycloalkyl methyl)-acetamido azetidin-2-one derivatives as cysteine proteinase regulators
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BACKGROUND OF THE INVENTION
Cysteine proteinases containing a highly reactive cysteine residue with a free thiol group at the active site have been known as playing an important role in certain conditions distinguished by aberrant protein turnover such as: muscular dystrophy (Am. J. Pathol. 1986,
Substituted amino bicyclic-.beta.-lactam penam and cepham derivatives as cysteine protease inhibitors
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BACKGROUND OF INVENTION
Cysteine proteases, such as cathepsins B, H, K, L, S, and O.sub.2, containing a highly reactive cysteine residue with a free thiol group at the active site have been known as playing an important role in certain conditions distinguished by aberrant protein turnover such as:
Sulfonamide derivatives
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to a novel sulfonamide derivative. More particularly, it relates to a novel sulfonamide derivative or a salt thereof which shows a strong inhibitory activity against cysteine protease such as calpain, cathepsin B,
Heteroaryl nitriles
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BACKGROUND OF THE INVENTION
Cysteine proteases have been viewed as lysosomal mediators of terminal protein degradation. Several newly discovered members of this enzyme class, however, are regulated proteases with limited tissue expression, which implies specific roles in cellular physiology and thus
Pulmonary delivery of NO group-containing compound in gas form to treat respiratory, cardiac and blood disorders
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TECHNICAL FIELD
This invention relates to the treatment of respiratory, cardiac and blood disorders by delivery into the lungs of compound comprising NO.
BACKGROUND OF THE INVENTION
Inhaled NO is used to treat elevated pulmonary pressures and pulmonary disorders associated with hypoxemia. This
Method of treating cardio pulmonary diseases with no group compounds
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TECHNICAL FIELD
This invention relates to the treatment of respiratory, cardiac and blood disorders by delivery into the lungs of compound comprising NO substitute.
BACKGROUND OF THE INVENTION
Inhaled NO is used to treat elevated pulmonary pressures and pulmonary disorders associated with hypoxemia.
Methods for the assay of troponin I and T and complexes of troponin I and T and selection of antibodies for use in immunoassays
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TECHNICAL FIELD
This invention relates to the assay of troponin I and troponin T and complexes of these proteins, and more specifically to the changes in conformation of these proteins in blood, serum and plasma and to the selection of antibodies to the various forms of these proteins and their use
Methods for the assay of troponin I and T and complexes of troponin I and T and selection of antibodies for use in immunoassays
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TECHNICAL FIELD
This invention relates to the assay of troponin I and troponin T and complexes of these proteins, and more specifically to the changes in conformation of these proteins in blood, serum and plasma and to the selection of antibodies to the various forms of these proteins and their use
Methods for the assay of troponin I and T and complexes of troponin I and T and selection of antibodies for use in immunoassays
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TECHNICAL FIELD
This invention relates to the assay of troponin I and troponin T and complexes of these proteins, and more specifically to the changes in conformation of these proteins in blood, serum and plasma and to the selection of antibodies to the various forms of these proteins and their use
Methods for the assay of troponin I and T and complexes of troponin I and T and selection of antibodies for use in immunoassays
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TECHNICAL FIELD
This invention relates to the assay of troponin I and troponin T and complexes of these proteins, and more specifically to the changes in conformation of these proteins in blood, serum and plasma and to the selection of antibodies to the various forms of these proteins and their use
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