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14 hasil
Cysteine-lowering Treatment With Mesna
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In both animal experiments and human studies, cysteine in the blood is strongly associated with obesity. In rodents, changes in cysteine induced by dietary means are accompanied by changes in fat mass.
In this phase I, single ascending dose study the investigators will determine the effects of Mesna
Evaluation of Thiosulfate in End Stage Renal Disease and Kidney Transplantation
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The rise in the incidence of end stage renal disease (ESRD) is both a national and international concern. Renal transplantation is currently the best available treatment for established renal failure as it not only offers freedom from dialysis but improves survival, provides better quality of life
N-acetyl-cysteine and Carbohydrate Metabolism Disorder in Obese Women
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The Efficacy of Individualized Dietary Advice in Improving Diet Quality and Cardiovascular Health
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Study design: a randomized controlled parallel group dietary intervention will be conducted over six months in participants at high risk of CVD living in Ireland (North and South) to evaluate the efficacy of individualized dietary advice incorporating biomarker profiles in improving diet quality and
Methionine and Cysteine Restriction in Humans
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The sulfur-containing amino acid methionine and its downstream metabolite cysteine has been associated with fat mass in animal studies and human observational studies. Some of the proposed mechanisms include an association with lipogenesis, insulin sensitivity and disrupted energy metabolism.
The
Effects of Dietary Amino Acids on Serum and Macrophage Atherogenicity
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Atherosclerosis is the underlying cause of cardiovascular diseases (CVD), the major cause of death worldwide. Atherosclerosis is an inflammatory disease of the arteries in which activated macrophages are abundant in the atherosclerotic lesions. Macrophages play key roles during early atherogenesis.
CALERIE Phase II Ancillary: Metabolic
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Hypothesis 1: The decrease in energy expenditure (sedentary and sleeping) will be larger than that expected on the basis of loss of fat-free mass and fat mass even after weight stabilization. Aim 1: Determine the metabolic adaptation after 1 and 2 years of a 25% CR
Hypothesis 2: The metabolic
Stearoyl-CoA Desaturase and Energy Metabolism in Humans
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In rodents as well as humans, high stearoyl-coenzyme A desaturase-1 (SCD1) activity is considered to be involved in development of obesity. In animal models, polyunsaturated fatty acids (PUFA) inhibit Scd1 gene expression and at the population level, dietary PUFA and plasma PUFA show strong inverse
Growth and Metabolism in Infants Fed Protein-reduced, Alpha-lactalbumin Enriched Formula
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Background: Breast milk is the best source of nutrition for the rapidly growing infant since it contains all the necessary nutrients in the right proportions. If the mother cannot breast-feed, chooses not to breast-feed or has to stop early, an adapted formula is from a nutritional perspective the
Fatty Liver Disease in Obese Children
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Physical activity (PA)-induced weight reduction, the suggested therapy for noalcoholic liver disease (NAFLD), is difficult and its maintenance is typically unsuccessful in children, affirming the acute need for alternative/adjunct therapies. Although few promising approaches have been reported, the
Glutathione and Fuel Oxidation in Aging
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Subjects will be recruited by written informed consent on forms approved by the Institutional Review Board of Baylor College of Medicine at the time of approval of the full protocol. Subjects taking an nonvitamin supplements or lipid lowering medications will stop this 4 weeks before the screening
Effects of Dietary Protein on Undesirable Postprandial Events in Overweight Subjects
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A Preliminary Study to Evaluate Cysteamine Therapy in Human Subjects With Non-Alcoholic Steatohepatitis (NASH)
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Non-alcoholic fatty liver disease (NAFLD) steatohepatitis represents a spectrum of disease occurring in the absence of alcohol abuse. It is characterized by the presence of steatosis and may represent a hepatic manifestation of the metabolic syndrome (including obesity, diabetes and
Effect of an Anti-Oxidant Treatment on Resistin Serum Levels.A Randomized Study
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INTRODUCTION
Background
Resistin, a recently described adipokine, belonging to the cysteine-rich secretory protein family, was originally described as an adipocyte-derived polypeptide, that provides the link between obesity and insulin resistance in mice1-2. However, resistin is expressed at very
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