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cysteine/stroke

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10 hasil
BACKGROUND OF THE INVENTION Field of the Invention The present invention relates generally to the use of .gamma.-glutamyl-D-cysteine as a cytoprotective agent to prevent reperfusion injury of the blood-brain barrier that may contribute to hemorrhagic transformation due to thrombolysis following an

Cysteine prodrugs

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FIELD OF THE INVENTION This invention relates to novel cysteine prodrugs and methods of using these compounds for the treatment of diseases and/or conditions, including but not limited to diseases and/or conditions of the Central Nervous System (CNS), including but not limited to schizophrenia, drug

Cytoprotective thereapeutic agents for the prevention of reperfusion injury following ischemic stroke

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BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates generally to the use of .gamma.-glutamyl antioxidants, particularly .gamma.-glutamyl -cysteine, as cytoprotective agents to prevent reperfusion injury (i.e., hemorrhagic transformation) of the blood-brain barrier

Cytoprotective therapeutic agents for the prevention of reperfusion injury following ischemic stroke

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BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates generally to the use of .gamma.-glutamyl antioxidants, particularly .gamma.-glutamyl-cysteine, as cytoprotective agents to prevent reperfusion injury (i.e., hemorrhagic transformation) of the blood-brain barrier

Sulfonamide derivatives

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BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a novel sulfonamide derivative. More particularly, it relates to a novel sulfonamide derivative or a salt thereof which shows a strong inhibitory activity against cysteine protease such as calpain, cathepsin B,

Arylsulfonamide ethers, and methods of use thereof

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FIELD OF THE INVENTION The invention relates to compounds that are inhibitors of interleukin-1.beta. converting enzyme. The invention also relates to pharmaceutical compositions comprising a compound of the present invention. The invention also relates to methods of treating stroke, inflammatory

Heteroaryl nitriles

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BACKGROUND OF THE INVENTION Cysteine proteases have been viewed as lysosomal mediators of terminal protein degradation. Several newly discovered members of this enzyme class, however, are regulated proteases with limited tissue expression, which implies specific roles in cellular physiology and thus

Aza-peptide epoxides

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BACKGROUND OF THE INVENTION 1. Field of the Invention This invention relates generally to protease inhibitors and applications thereof, more specifically to peptide inhibitors of cysteine proteases, even more specifically to aza-peptide epoxides, methods of their use, and methods of their

Beta-amino acid nitrile derivatives as cathepsin K inhibitors

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FIELD OF THE INVENTION The present invention relates to novel beta-amino acid nitrile derivatives, their manufacture and use as medicaments. In particular, the invention relates to novel beta-amino acid nitrile derivatives of formula (I) ##STR1## wherein R.sup.1 represents hydrogen, aryl,

Synthetic apelin fatty acid conjugates with improved half-life

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FIELD OF THE INVENTION The present invention relates to compositions comprising semi synthetic biologic molecules which are bioconjugates of an APJ agonist polypeptide and a fatty acid moiety. In particular, the bioconjugates of the invention, while retaining APJ agonistic activity, exhibit greater
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