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diabetes mellitus/phosphatase
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Preparation of phosphatase inhibitors
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FIELD OF THE INVENTION
This invention relates to the preparation of phosphatase inhibitors that act as phosphotyrosine mimetics. The invention particularly relates to compounds designed to inhibit protein-tyrosine phosphatase 1B, and for the treatment of diabetes.
SUMMARY OF THE RELATED ART
Protein
Preparation of phosphatase inhibitors
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BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to the preparation of phosphatase inhibitors that act as phosphotyrosine mimetics. The invention particularly relates to compounds designed to inhibit protein-tyrosine phosphatase 1B, and for the treatment of diabetes.
2.
PTP1B inhibitors, synthesis thereof and application thereof in preparation of medicaments for treating type 2 diabetes mellitus
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FIELD OF THE INVENTION
This invention is in the field of biological medicine and specifically relates to the preparation, pharmacological activities and application of twelve bromophenol compounds, including: (2'-bromo-6'-(dibromomethyl)-3',4'-dimethoxyphenyl)-(2,3-dibromo-4,5-dime-
Methods of inhibiting phosphatase activity and treatment of disorders associated therewith
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1. INTRODUCTION
The present invention relates to compounds capable of modulating and/or regulating the activity of phosphotyrosine phosphatases that regulate signal transduction. Specifically, the present invention relates to the use of such compounds for the treatment of diseases caused by
Methods of inhibiting phosphatase activity and treatment of disorders associated therewith using naphthopyrones and derivatives thereof
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1. INTRODUCTION
The present invention relates to compounds capable of modulating and/or regulating the activity of phosphotyrosine phosphatases that regulate signal transduction. Specifically, the present invention relates to the use of such compounds for the treatment of diseases caused by
Methods of inhibiting phosphatase activity and treatment of disorders associated therewith using naphthopyrones and derivatives thereof
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1. INTRODUCTION
2. BACKGROUND OF THE INVENTION
2.1. Signal Transduction
2.2. Protein Tyrosine Kinases And Phosphatases
2.3. Abnormal Signal Transduction In Human Diseases
3. SUMMARY OF THE INVENTION
3.1. Definitions
4. BRIEF DESCRIPTION OF THE DRAWINGS
5. DETAILED DESCRIPTION OF THE INVENTION
5.1.
Inhibitors of protein tyrosine phosphatase
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FIELD OF THE INVENTION
The present invention comprises small molecular weight, non-peptidic inhibitors of Protein Tyrosine Phosphatase 1 (PTP1) which are useful for the treatment and/or prevention of Non-Insulin Dependent Diabetes Mellitus (NIDDM).
BACKGROUND OF THE INVENTION
The mechanism of
Inhibitors of protein tyrosine phosphatase
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The present invention comprises small molecular weight, non-peptidic inhibitors of Protein Tyrosine Phosphatase 1 (PTP1) which are useful for the treatment and/or prevention of Non-Insulin Dependent Diabetes Mellitus (NIDDM).
BACKGROUND OF THE INVENTION
The mechanism of insulin action depends
1,2,5-thiazolidine derivatives useful for treating conditions mediated by protein tyrosine phosphatases (PTPase)
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This application is the National Stage of Application No. PCT/EP2006/046543, filed on Dec. 6, 2006, which claims benefit under 35 U.S.C. .sctn.119(a-d) of U.S. Provisional Application No. 60/748,491, filed Dec. 8, 2005, the contents of which are incorporated herein by reference in their
Treatment of diabetes mellitus and insulin receptor signal transduction
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1. INTRODUCTION
The present invention relates to novel modalities for treatment of diabetes, and other diseases caused by dysfunctional signal transduction by receptor type tyrosine kinases, in particular the insulin receptor.
The present invention further relates to methods for screening and
Substituted arylsulfonylaminomethylphosphonic acid derivatives, their preparation and their use in the treatment of type I and II diabetes mellitus
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This application is the national stage filing under 35 U.S.C. .sctn.371 of International Application No. PCT/EP2008/059805, filed Jul. 25, 2008, which claims the benefit of German Patent Application No. DE102007035333.4, filed Jul. 27, 2007, each of which is incorporated by reference in its
Substituted arylsulfonylaminomethylphosphonic acid derivatives, their preparation and their use in the treatment of type I and II diabetes mellitus
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This application is the national stage filing under 35 U.S.C. .sctn.371 International Application No. PCT/EP2008/059807, filed Jul. 25, 2008, which claims the benefit of German Application No. DE102007035334.2, filed Jul. 27, 2007, each of which is incorporated by reference in its entirety.
The
Islet cell antigen 1851
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BACKGROUND OF THE INVENTION
Detection of specific autoantigens in prediabetic individuals has been used as a predictive marker to identify, before clinical onset and significant .beta.-cell loss has occurred, those at greater risk of developing IDDM (Gorsuch et al., Lancet 2: 1363-65, 1981;
Islet cell antigen 1851
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BACKGROUND OF THE INVENTION
Insulin-dependent diabetes mellitus (IDDM) is a disease resulting from the autoimmune destruction of the insulin-producing .beta.-cells of the pancreas. Studies directed at identifying the autoantigen(s) responsible for .beta.-cell destruction have generated several
Thiazole compounds and methods of modulating signal transduction
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1. INTRODUCTION
The present invention relates to compounds capable of modulating and/or regulating the activity of phosphotyrosine phosphatases that regulate signal transduction. Specifically, the present invention relates to the use of such compounds for the treatment of diseases caused by
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