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SUMMARY OF THE INVENTION
Dodecapeptides of the formula: ##STR2## where
X.sub.1 is either D- or L- Lys, Arg, His or Orn;
X.sub.2 is either D- or L- Asn, His, Glu, Asp, Tyr or Trp;
X.sub.3 is either D- or L- Trp;
the linear precursor intermediates thereof and pharmaceutically acceptable salts and
BACKGROUND OF INVENTION
The use of aldose reductase inhibitors (ARIs) for the treatment of diabetic complications is well known. The complications arise from elevated levels of glucose in tissues such as the nerve, kidney, retina and lens that enters the polyol pathway and is converted to sorbitol
BACKGROUND OF INVENTION
The use of aldose reductase inhibitors (ARIs) for the treatment of diabetic complications is well known. The complications arise from elevated levels of glucose in tissues such as the nerve, kidney, retina and lens that enters the polyol pathway and is converted to sorbitol
DESCRIPTION
This invention relates to the use of nucleic acid sequences of the MAP kinase-interacting kinase (Mnk) gene family and amino acid sequences encoded thereby, and to the use of these sequences or effectors of Mnk nucleic acids or polypeptides, particularly Mnk kinase inhibitors and
CROSS-REFERENCE TO RELATED APPLICATIONS
This application claims priority to PCT Patent Application No. PCT/EP02/03540 filed Mar. 28, 2002 and European Patent Applications No. EP01 108 315.1 filed Apr. 2, 2001 and EP01 113 419.4 filed Jun. 1, 2001.
DESCRIPTION
This invention relates to the use of
DESCRIPTION
This invention relates to the use of nucleic acid and amino acid sequences of protein disulfide isomerase and ABC transporter homologous proteins, and to the use of these sequences in the diagnosis, study, prevention, and treatment of diseases and disorders related to body-weight
PRIORITY
The present application claims the benefit of Indian Provisional Patent Application No. 1853/CHE/2012 filed on 10 May 2012 and the International Application No. PCT/IB2013/051596 filed on 28 Feb. 2013, the entire disclosure of which is relied on for all purposes and is incorporated into
FIELD OF THE INVENTION
This invention relates to compounds which are dialkyl ethers having terminal carboxy or tetrazole groups. The compounds are useful for lowering certain plasma lipids in animals, including Lp(a), triglycerides, VLDL-cholesterol, and LDL-cholesterol, and elevating others such as
FIELD OF THE INVENTION
This invention relates to compounds which are dialkyl ethers having terminal carboxy or tetrazole groups. The compounds are useful for lowering certain plasma lipids in animals, including Lp(a), triglycerides, VLDL-cholesterol, and LDL-cholesterol, and elevating others such as
BACKGROUND OF THE INVENTION
Vascular diseases such as coronary heart disease, stroke, restenosis, and peripheral vascular disease, remain the leading cause of death and disability throughout the world. About 1.5 million people die each year in the US alone from myocardial infarction resulting from
FIELD OF THE INVENTION
This invention relates to compounds which are dialkyl ethers having terminal carboxy or tetrazole groups. The compounds are useful for lowering certain plasma lipids in animals, including Lp(a), triglycerides, VLDL-cholesterol, and LDL-cholesterol, and elevating others such as
FIELD OF THE INVENTION
This invention relates to the use of crude Dunaliella bardawil powder in the treatment of a number of conditions including high triglyceride and low high-density lipoprotein (HDL) cholesterol levels, atherosclerosis and diabetes.
REFERENCES
The following is a list of
FIELD OF THE INVENTION
This invention relates to the use of crude Dunaliella bardawil powder in the treatment of a number of conditions including high triglyceride and low high-density lipoprotein (HDL) cholesterol levels, atherosclerosis and diabetes.
REFERENCES
The following is a list of
FIELD OF THE INVENTION
This invention relates to the use of crude Dunaliella bardawil powder in the treatment of a number of conditions including high triglyceride and low high-density lipoprotein (HDL) cholesterol levels, atherosclerosis and diabetes.
REFERENCES
The following is a list of
BACKGROUND OF INVENTION
1. Field of the Invention
The present invention relates to pharmaceutical compositions, and in particular to pharmaceutical compositions containing an aldose reductase inhibitor (ARI) and an angiotensin converting enzyme (ACE) inhibitor, is useful in the prevention and